Contrast enhancement in atherosclerosis development in a mouse model:: in vivo results at 2Tesla

被引:23
作者
Chaabane, L
Pellet, N
Bourdillon, MC
Mansard, CD
Sulaiman, A
Hadour, G
Thivolet-Béjui, F
Roy, P
Briguet, A
Douek, P
Soulas, EC
机构
[1] Hop Cardiol, CNRS UMR 5515, CREATIS, F-69500 Bron, France
[2] Univ Lyon 1, UMR CNRS 5012, Lab RMN, ESCPE, F-69622 Villeurbanne, France
[3] Univ Lyon 1, Fac Med Laennec, F-69372 Lyon, France
[4] Hop Cardiol, Hop Cardiol, Dept Pathol Cardiovasc & Pneumol, F-69500 Bron, France
[5] Hop Lyon Sud, Hospices Civils Lyon, Dept Biostat, F-69495 Pierre Benite, France
关键词
medial remodelling; atherosclerosis; permeability; apolipoprotein E knockout mice; magnetic resonance imaging;
D O I
10.1007/s10334-004-0055-7
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To develop an MRI method for the evaluation of contrast enhancement in early atherosclerotic plaque development in the abdominal aorta of a mouse model. Male apoE(-/-) mice from three groups, respectively 4 (n = 6), 8 (n = 11) and 16 (n = 4) weeks were included. Axial T I spin echo images of the abdominal aorta were obtained above and below the renal arteries (90 mu m spatial resolution) before and over 1 h after the injection of a macromolecular contrast agent. Signal enhancement was measured in the vessel wall and compared to histological features. Maximal arterial wall signal enhancement was obtained from 16 to 32 min post injection. During this time, the signal-to-noise ratio increased by a factor up to 1.7 in 16 week mice and 2.7 and 2.4 in 8 and 4 weeks mice, respectively. The enhancement of the arterial wall appeared less pronounced in the oldest mice, 16 weeks old, exhibiting more advanced lesions. Using a macromolecular gadolinium agent, contrast uptake in atherogenesis varies with lesion stage and may be related to vessel-wall permeability. Dynamic contrast-enhanced MRI may be useful to evaluate the atherosclerotic plaque activity in mice.
引用
收藏
页码:188 / 195
页数:8
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