Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner

被引：14

作者：

Saeki, Noritaka ^{[1
,2
]}

Inoue, Kazuki ^{[3
]}

Ideta-Otsuka, Maky ^{[4
]}

Watamori, Kunihiko ^{[5
]}

Mizuki, Shinichi ^{[6
]}

Takenaka, Katsuto ^{[7
]}

Igarashi, Katsuhide ^{[8
,9
]}

Miura, Hiromasa ^{[5
]}

Takeda, Shu ^{[10
]}

Imai, Yuuki ^{[1
,2
,11
]}

机构：

[1] Ehime Univ, Adv Res Support Ctr, Div Lab Anim Res, Toon, Ehime, Japan

[2] Ehime Univ, Proteosci Ctr, Div Integrat Pathophysiol, Toon, Ehime, Japan

[3] Nankai Univ, Nankai Int Adv Res Inst Shenzhen Futian, Shenzhen, Peoples R China

[4] Hoshi Univ, Sch Pharm & Pharmaceut Sci, Lab Instrumental Anal, Shinagawa Ku, Tokyo, Japan

[5] Ehime Univ, Grad Sch Med, Dept Bone & Joint Surg, Toon, Ehime, Japan

[6] Matsuyama Red Cross Hosp, Ctr Rheumat Dis, Matsuyama, Ehime, Japan

[7] Ehime Univ, Grad Sch Med, Dept Hematol Clin Immunol & Infect Dis, Toon, Ehime, Japan

[8] Hoshi Univ, Sch Pharm & Pharmaceut Sci, Lab Biofunct Sci, Shinagawa Ku, Tokyo, Japan

[9] Hoshi Univ, Inst Adv Life Sci, Shinagawa Ku, Tokyo, Japan

[10] Toranomon Gen Hosp, Endocrine Ctr, Div Endocrinol, Minato Ku, Tokyo, Japan

[11] Ehime Univ, Grad Sch Med, Dept Pathophysiol, Toon, Ehime, Japan

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2022年 / 132卷 / 11期

基金：

日本学术振兴会;

关键词：

DNA METHYLOME SIGNATURE; WIDE ASSOCIATION; T-CELLS; METHYLATION; HYPOMETHYLATION; PROLIFERATION; RECOGNITION; INHIBITION; ACTIVATION; MATURATION;

D O I：

10.1172/JCI150533

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation with aberrant epigenetic alterations, eventually leading to joint destruction. However, the epigenetic regulatory mechanisms underlying RA pathogenesis remain largely unknown. Here, we showed that ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) is a central epigenetic regulator that orchestrates multiple pathogeneses in RA in a suppressive manner. UHRF1 expression was remarkably Finally, Ryuvidine administration stabilized UHRF1 ameliorated arthritis pathogeneses in a mouse model of RA. This study pathogenic events in arthritis, suggesting that targeting UHRF1 could be one of the therapeutic strategies for RA.

引用

页数：17

共 25 条

[21] CD47 Activation-induced UHRF1 Over-expression Is Associated with Silencing of Tumor Suppressor Gene p16INK4A in Glioblastoma Cells
Boukhari, Abdelaziz
Alhosin, Mahmoud
Bronner, Christian
Sagini, Krizia
Truchot, Cecile
Sick, Emilie
Schini-Kerth, Valerie B.
Andre, Philippe
Mely, Yves
Mousli, Marc
Gies, Jean-Pierre
[J]. ANTICANCER RESEARCH, 2015, 35 (01) : 149 - 157
[22] Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line
Imamura, Hitoshi
Yoshina, Sawako
Ikari, Katsunori
Miyazawa, Keiji
Momohara, Shigeki
Mitani, Shohei
[J]. MODERN RHEUMATOLOGY, 2016, 26 (04) : 507 - 516
[23] Conventional DMARDs therapy decreases disease activity and inflammation in newly diagnosed patients with rheumatoid arthritis by increasing FoxP3, Sema-3A, and Nrp-1 gene expression
Soufivand, Parviz
Hosseini Torshizi, Ghazal
Roghani, Seyed Askar
Dastbaz, Mohammad
Lotfi, Ramin
Soleymani, Bijan
Heydarpour, Fatemeh
Abdan, Zahra
Allahyari, Hosna
[J]. INFLAMMOPHARMACOLOGY, 2024, 32 (06) : 3687 - 3695
[24] Immunopharmacological effect of β-d-mannuronic acid (M2000), as a new immunosuppressive drug, on gene expression of miR-155 and its target molecules (SOCS1, SHIP1) in a clinical trial on rheumatoid arthritis patients
Mortazavi-Jahromi, Seyed Shahabeddin
Aslani, Mona
Omidian, Saiedeh
Ahmadzadeh, Arman
Rezaieyazdi, Zahra
Mirshafiey, Abbas
[J]. DRUG DEVELOPMENT RESEARCH, 2020, 81 (03) : 295 - 304
[25] Gene expression analysis of rheumatoid arthritis synovial lining regions by cDNA microarray combined with laser microdissection: up-regulation of inflammation-associated STAT1, IRF1, CXCL9, CXCL10, and CCL5
Yoshida, S.
Arakawa, F.
Higuchi, F.
Ishibashi, Y.
Goto, M.
Sugita, Y.
Nomura, Y.
Niino, D.
Shimizu, K.
Aoki, R.
Hashikawa, K.
Kimura, Y.
Yasuda, K.
Tashiro, K.
Kuhara, S.
Nagata, K.
Ohshima, K.
[J]. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2012, 41 (03) : 170 - 179

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