Emerging drugs for bronchiectasis

被引:11
作者
Chang, Anne B. [1 ,2 ]
Marsh, Robyn L. [2 ]
Smith-Vaughan, Heidi C. [2 ]
Hoffman, Lucas R. [3 ,4 ]
机构
[1] Royal Childrens Hosp, Queensland Childrens Resp Ctr, Queensland Childrens Med Res Inst, Brisbane, Qld 4029, Australia
[2] Charles Darwin Univ, Menzies Sch Hlth Res, Child Hlth Div, Darwin, NT 0909, Australia
[3] Univ Washington, Dept Pediat, Seattle, WA 98195 USA
[4] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
基金
英国医学研究理事会;
关键词
adults; bronchiectasis; children; cough; treatment; CYSTIC-FIBROSIS BRONCHIECTASIS; QUALITY-OF-LIFE; OBSTRUCTIVE PULMONARY-DISEASE; SUPPURATIVE LUNG-DISEASE; HIGH-RESOLUTION CT; INDIGENOUS CHILDREN; ACUTE EXACERBATIONS; BRONCHOARTERIAL RATIO; HYPEROSMOLAR AGENTS; INFECTIOUS-DISEASES;
D O I
10.1517/14728214.2012.702755
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: The global burden of disease due to bronchiectasis is high, disproportionately impacting developing countries and disadvantaged populations. Bronchiectasis, the destruction and dilation of airways, is due to a variety of causes and is characterized by a self-perpetuating cycle of airway inflammation, infection and obstruction that results in substantial morbidity and mortality. Although many therapies have been tested that address each of these three components, as well as the diseases that both cause and result from bronchiectasis, there have been few randomized, placebo-controlled trials. Areas covered: In this review, current knowledge of the clinical features, pathophysiology and epidemiology of bronchiectasis among both adults and children is summarized. We discuss the quality and extent of evidence supporting current treatment strategies, focusing on therapies for which the strongest evidence of efficacy exists. We then identify key goals for future research on the causes and treatments of a variety of types of bronchiectasis. Expert opinion: Significant advances in the prevention and treatment of bronchiectasis will require substantially improved understanding of the pathogenesis of this orphan disease. A concerted, global effort to coordinate studies of both the pathophysiology and potential treatments of bronchiectasis, in its many forms, could lead to substantial improvements in outcomes.
引用
收藏
页码:361 / 378
页数:18
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