Building biological foundries for next-generation synthetic biology

被引：22

作者：

Chao Ran ^{[1
,2
]}

Yuan YongBo ^{[2
]}

Zhao HuiMin ^{[1
,2
,3
]}

机构：

[1] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Bioengn, Dept Chem, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA

来源：

SCIENCE CHINA-LIFE SCIENCES | 2015年 / 58卷 / 07期

基金：

美国国家卫生研究院;

关键词：

biofabrication; automation; metabolic engineering; biosystems design; DNA assembly; DNA sequencing; metabolite analysis; COMBINATORIAL GENETIC-TRANSFORMATION; SUBTILIS GENOME VECTOR; HIGH-THROUGHPUT; HOMOLOGOUS RECOMBINATION; SACCHAROMYCES-CEREVISIAE; MASS-SPECTROMETRY; DIRECT CLONING; CAROTENOID PATHWAY; ESCHERICHIA-COLI; SINGLE CELLS;

D O I：

10.1007/s11427-015-4866-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Synthetic biology is an interdisciplinary field that takes top-down approaches to understand and engineer biological systems through design-build-test cycles. A number of advances in this relatively young field have greatly accelerated such engineering cycles. Specifically, various innovative tools were developed for in silico biosystems design, DNA de novo synthesis and assembly, construct verification, as well as metabolite analysis, which have laid a solid foundation for building biological foundries for rapid prototyping of improved or novel biosystems. This review summarizes the state-of-the-art technologies for synthetic biology and discusses the challenges to establish such biological foundries.

引用

页码：658 / 665

页数：8

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