The Transcription Factor GATA3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells

被引：702
|
作者：
Hoyler, Thomas [1 ,2 ]
Klose, Christoph S. N. [1 ,3 ]
Souabni, Abdallah [4 ]
Turqueti-Neves, Adriana [5 ,6 ]
Pfeifer, Dietmar [7 ]
Rawlins, Emma L. [8 ]
Voehringer, David [5 ,6 ]
Busslinger, Meinrad [4 ]
Diefenbach, Andreas [1 ,2 ,3 ,9 ]
机构：
[1] Univ Freiburg, IMMH, D-79104 Freiburg, Germany
[2] Univ Freiburg, Res Training Grp Organogenesis GRK1104, D-79104 Freiburg, Germany
[3] Univ Freiburg, Spemann Grad Sch Biol & Med, D-79104 Freiburg, Germany
[4] Vienna Bioctr, Res Inst Mol Pathol, A-1020 Vienna, Austria
[5] Univ Erlangen Nurnberg, D-91054 Erlangen, Germany
[6] Univ Klinikum Erlangen, Inst Med Microbiol Immunol & Hyg, Dept Infect Biol, D-91054 Erlangen, Germany
[7] Univ Freiburg, Med Ctr Freiburg, Dept Internal Med 1, Core Facil Genom, D-79106 Freiburg, Germany
[8] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
[9] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79104 Freiburg, Germany
来源：
IMMUNITY | 2012年 / 37卷 / 04期
关键词：
FUNCTION-ASSOCIATED ANTIGEN; ROR-GAMMA-T; CUTTING EDGE; KILLER-CELL; EXPRESSION; HOMEOSTASIS; POPULATION; IMMUNITY; CADHERIN; FAMILY;
D O I：
10.1016/j.immuni.2012.06.020
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Innate lymphoid cells (ILCs) reside at mucosal surfaces and control immunity to intestinal infections. Type 2 innate lymphoid cells (ILC2s) produce cytokines such as IL-5 and IL-13, are required for immune defense against helminth infections, and are involved in the pathogenesis of airway hyperre-activity. Here, we have investigated the role of the transcription factor GATA-3 for ILC2 differentiation and maintenance. We showed that ILC2s and their lineage-specified bone marrow precursors (ILC2Ps), as identified here, were characterized by continuous high expression of GATA-3. Analysis of mice with temporary deletion of GATA-3 in all ILCs showed that GATA-3 was required for the differentiation and maintenance of ILC2s but not for ROR gamma t(+) ILCs. Thus, our data demonstrate that GATA-3 is essential for ILC2 fate decisions and reveal similarities between the transcriptional programs controlling ILC and T helper cell fates.
引用
收藏
页码：634 / 648
页数：15
相关论文
共 50 条
  • [1] Gata3 controls cell fate and maintenance of type 2 innate lymphoid cells
    Hoyler, T.
    Klose, C.
    Souabni, A.
    Busslinger, M.
    Turqueti-Neves, A.
    Voehringer, D.
    Diefenbach, A.
    IMMUNOLOGY, 2012, 137 : 99 - 99
  • [2] Gata3 controls cell fate and maintenance of type 2 innate lymphoid cells
    Hoyler, T.
    Klose, C.
    Souabni, A.
    Turqueti-Neves, A.
    Voehringer, D.
    Busslinger, M.
    Diefenbach, A.
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2012, 302 : 122 - 123
  • [3] The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells
    Mjosberg, Jenny
    Bernink, Jochem
    Golebski, Korneliusz
    Karrich, Julien J.
    Peters, Charlotte P.
    Blom, Bianca
    te Velde, Anje A.
    Fokkens, Wytske J.
    van Drunen, Cornelis M.
    Spits, Hergen
    IMMUNITY, 2012, 37 (04) : 649 - 659
  • [4] Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells
    Zhong, Chao
    Zheng, Mingzhu
    Cui, Kairong
    Martins, Andrew J.
    Hu, Gangqing
    Li, Dan
    Tessarollo, Lino
    Kozlov, Serguei
    Keller, Jonathan R.
    Tsang, John S.
    Zhao, Keji
    Zhu, Jinfang
    IMMUNITY, 2020, 52 (01) : 83 - +
  • [5] The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells
    Yagi, Ryoji
    Zhong, Chao
    Northrup, Daniel L.
    Yu, Fang
    Bouladoux, Nicolas
    Spencer, Sean
    Hu, Gangqing
    Barron, Luke
    Sharma, Suveena
    Nakayama, Toshinori
    Belkaid, Yasmine
    Zhao, Keji
    Zhu, Jinfang
    IMMUNITY, 2014, 40 (03) : 378 - 388
  • [6] T-bet and Gata3 in controlling type 1 and type 2 immunity mediated by innate lymphoid cells
    Hoyler, Thomas
    Connor, Catherine A.
    Kiss, Elina A.
    Diefenbach, Andreas
    CURRENT OPINION IN IMMUNOLOGY, 2013, 25 (02) : 139 - 147
  • [7] Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells
    Wolterink, Roel G. J. Klein
    Serafini, Nicolas
    van Nimwegen, Menno
    Vosshenrich, Christian A. J.
    de Bruijn, Marjolein J. W.
    Pereira, Diogo Fonseca
    Fernandes, Henrique Veiga
    Hendriks, Rudi W.
    Di Santo, James P.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (25) : 10240 - 10245
  • [8] Staying innate: transcription factor maintenance of innate lymphoid cell identity
    Di Santo, James P.
    IMMUNOLOGICAL REVIEWS, 2014, 261 (01) : 169 - 176
  • [9] Transient Expression of GATA3 in Hematopoietic Stem Cells Facilitates Helper Innate Lymphoid Cell Differentiation
    Tufa, Dejene M.
    Yingst, Ashley M.
    Shank, Tyler
    Shim, Seonhui
    Trahan, George Devon
    Lake, Jessica
    Woods, Renee
    Jones, Kenneth L.
    Verneris, Michael R.
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [10] Gata3 drives development of RORγt+ group 3 innate lymphoid cells
    Serafini, Nicolas
    Wolterink, Roel G. J. Klein
    Satoh-Takayama, Naoko
    Xu, Wei
    Vosshenrich, Christian A. J.
    Hendriks, Rudi W.
    Di Santo, James P.
    JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 211 (02): : 199 - 208
12345