Catalytic Asymmetric Sulfenylation of Unprotected 3-Substituted Oxindoles

被引：96

作者：

Cai, Yunfei ^{[1
]}

Li, Jun ^{[1
]}

Chen, Weiliang ^{[1
]}

Xie, Mingsheng ^{[1
]}

Liu, Xiaohua ^{[1
]}

Lin, Lili ^{[1
]}

Feng, Xiaoming ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 11期

基金：

中国国家自然科学基金;

关键词：

C-H; FLUORINATION; COMPLEXES;

D O I：

10.1021/ol3009446

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic asymmetric sulfenylation of unprotected 3-substituted oxindoles has been developed via cooperative catalysis of a chiral N,N-dioxide-Sc(OTf)(3) complex and a Bronsted base. Utilizing readily available N-(phenylthio)phthalimide as the sulfur source, a wide range of optically active 3-phenylthiooxindoles were obtained in excellent yields with excellent enantioselectivities under mild reaction conditions.

引用

收藏

页码：2726 / 2729

页数：4

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