Chemical Constituents of the Underground Parts of Iris florentina and their Cytotoxic Activity

被引：0
|
作者：
Yokosuka, Akihito [1 ]
Koyama, Yoshikazu [1 ]
Mimaki, Yoshihiro [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, Dept Med Pharmacognosy, Sch Pharm, Hachioji, Tokyo 1920392, Japan
来源：
NATURAL PRODUCT COMMUNICATIONS | 2015年 / 10卷 / 06期
关键词：
Iris florentina; Iridaceae; Isoflavonoid glycoside; HL-60; cell; Cytotoxic activity; ISOFLAVONE; GERMANICA;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new isoflavonoid glycosides (1, 5, and 9) and 10 known compounds (2-4, 6-8, and 10-13) were isolated from the underground parts of Iris florentina (Iridaceae). The structures of the new compounds were determined based on extensive spectroscopic data and the results of hydrolytic cleavage. The isolated compounds and the aglycones were evaluated for cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 12 induced apoptotic cell death in the HL-60 cells.
引用
收藏
页码：955 / 958
页数：4
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