Simple microwave-assisted ligand-free Suzuki cross-coupling: Functionalization of halo-pyrimidine moieties

被引：17

作者：

Colombo, Matteo ^{[1
]}

Giglio, Marco ^{[1
]}

Peretto, Ilaria ^{[1
]}

机构：

[1] NiKem Res, I-20021 Milan, Italy

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2008年 / 45卷 / 04期

关键词：

D O I：

10.1002/jhet.5570450420

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An advantageous ligand-free protocol for Suzuki couplings is described. The synthetic procedure entails microwave irradiation for the reduction of the reaction times and the use of silica cartridges for the purification. Dihalo-pyrimidine structures, interesting scaffolds in medicinal chemistry, were chosen as test compounds.

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页码：1077 / 1081

页数：5

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