Synthesis of a PNA-peptide conjugate by chemical ligation

被引:0
作者
de Koning, MC [1 ]
Filippov, DV [1 ]
Meeuwenoord, N [1 ]
Overhand, M [1 ]
van der Marel, GA [1 ]
van Boom, JH [1 ]
机构
[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
关键词
native chemical ligation; PNA-peptide conjugate; nuclear localization signal; convergent synthesis;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A convergent synthetic route to the construction of a PNA-N-to-C-peptide conjugate (PKKKRKVGC-ttgcatt) by regioselective condensation of a thioester peptide and a cysteine-PNA adduct under denaturating conditions is described.
引用
收藏
页码:1516 / 1518
页数:3
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