Toward Hydrogen Sulfide Based Therapeutics: Critical Drug Delivery and Developability Issues

被引：144

作者：

Zheng, Yueqin ^{[1
]}

Yu, Bingchen ^{[1
]}

De La Cruz, Ladie Kimberly ^{[1
]}

Choudhury, Manjusha Roy ^{[1
]}

Anifowose, Abiodun ^{[1
]}

Wang, Binghe ^{[1
]}

机构：

[1] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

来源：

MEDICINAL RESEARCH REVIEWS | 2018年 / 38卷 / 01期

基金：

美国国家卫生研究院;

关键词：

hydrogen sulfide(H2S); gasotransmitter; hydrogen sulfide donors; H2S delivery; H2S prodrugs developability; INDUCED GASTRIC DAMAGE; ANIMATION-LIKE STATE; NITRIC-OXIDE; MYOCARDIAL-ISCHEMIA; DIALLYL TRISULFIDE; FLUORESCENT-PROBES; LAWESSONS REAGENT; CHEMICAL BIOLOGY; HEART-FAILURE; H2S DONORS;

D O I：

10.1002/med.21433

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hydrogen sulfide (H2S), together with nitric oxide (NO) and carbon monoxide (CO), belongs to the gasotransmitter family and plays important roles in mammals as a signaling molecule. Many studies have also shown the various therapeutic effects of H2S, which include protection against myocardial ischemia injury, cytoprotection against oxidative stress, mediation of neurotransmission, inhibition of insulin signaling, regulation of inflammation, inhibition of the hypoxia-inducible pathway, and dilation of blood vessels. One major challenge in the development of H2S-based therapeutics is its delivery. In this manuscript, we assess the various drug delivery strategies in the context of being used research tools and eventual developability as therapeutic agents.

引用

页码：57 / 100

页数：44

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