Integrative Hedonic and Homeostatic Food Intake Regulation by the Central Nervous System: Insights from Neuroimaging

被引:38
作者
Campos, Alejandro [1 ]
Port, John D. [2 ]
Acosta, Andres [1 ]
机构
[1] Mayo Clin, Precis Med Obes Program, Div Gastroenterol & Hepatol, Dept Med, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Diagnost Radiol, Rochester, MN 55905 USA
关键词
food intake regulation; reward; fMRI; hedonic eating; gut-brain axis; neuroimaging; INCENTIVE-SENSITIZATION THEORY; 5-HT2A RECEPTOR-BINDING; VENTRAL TEGMENTAL AREA; BODY-MASS INDEX; PEPTIDE YY PYY; BRAIN ACTIVITY; PHYSIOLOGICAL ROLES; NUCLEUS-ACCUMBENS; NEURONAL RESPONSE; TASTE PERCEPTION;
D O I
10.3390/brainsci12040431
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Food intake regulation in humans is a complex process controlled by the dynamic interaction of homeostatic and hedonic systems. Homeostatic regulation is controlled by appetitive signals from the gut, adipose tissue, and the vagus nerve, while conscious and unconscious reward processes orchestrate hedonic regulation. On the one hand, sight, smell, taste, and texture perception deliver potent food-related feedback to the central nervous system (CNS) and influence brain areas related to food reward. On the other hand, macronutrient composition stimulates the release of appetite signals from the gut, which are translated in the CNS into unconscious reward processes. This multi-level regulation process of food intake shapes and regulates human ingestive behavior. Identifying the interface between hormones, neurotransmitters, and brain areas is critical to advance our understanding of conditions like obesity and develop better therapeutical interventions. Neuroimaging studies allow us to take a glance into the central nervous system (CNS) while these processes take place. This review focuses on the available neuroimaging evidence to describe this interaction between the homeostatic and hedonic components in human food intake regulation.
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页数:26
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