Clinical Implications and Future Perspectives of Circulating Tumor Cells and Biomarkers in Clinical Outcomes of Colorectal Cancer

被引：39

作者：

Huang, Ming-Yii ^{[1
,2
,3
]}

Tsai, Hsiang-Lin ^{[4
,5
]}

Huang, Joh-Jong ^{[7
,8
]}

Wang, Jaw-Yuan ^{[3
,5
,6
]}

机构：

[1] Kaohsiung Med Univ Hosp, Dept Radiat Oncol, Ctr Canc, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Dept Radiat Oncol, Coll Med, Fac Med, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Grad Inst Med, Ctr Biomarkers & Biotech Drugs, Kaohsiung 807, Taiwan

[4] Kaohsiung Med Univ, Dept Surg, Div Gen Surg Med, Kaohsiung Med Univ Hosp, Kaohsiung 807, Taiwan

[5] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Gastroenterol & Gen Surg, Dept Surg, Kaohsiung 807, Taiwan

[6] Kaohsiung Med Univ, Grad Inst Clin Med, Dept Surg, Kaohsiung 807, Taiwan

[7] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 807, Taiwan

[8] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Community Med, Kaohsiung 807, Taiwan

来源：

TRANSLATIONAL ONCOLOGY | 2016年 / 9卷 / 04期

关键词：

SERUM CARCINOEMBRYONIC ANTIGEN; III COLON-CANCER; MULTIPLE MOLECULAR MARKERS; POLYMERASE-CHAIN-REACTION; POOR PROGNOSTIC-FACTOR; GROWTH-FACTOR RECEPTOR; PERIPHERAL-BLOOD; MICROSATELLITE INSTABILITY; CURATIVE RESECTION; RT-PCR;

D O I：

10.1016/j.tranon.2016.06.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is a major public health problem. Early CRC detection, pretherapeutic responsiveness prediction, and postoperative micrometastasis monitoring are the hallmarks for successful CRC treatment. Here, the methodologies used for detecting circulating tumor cells (CTCs) from CRC are reviewed. In addition to the traditional CRC biomarkers, the persistent presence of posttherapeutic CTCs indicates resistance to adjuvant chemotherapy and/or radiotherapy; hence, CTCs also play a decisive role in the subsequent relapse of CRC. Moreover, the genetic and phenotypic profiling of CTCs often differs from that of the primary tumor; this difference can be used to select the most effective targeted therapy. Consequently, studying CTCs can potentially individualize treatment strategies for patients with CRC. Therefore, CTC detection and characterization may be valuable tools for refining prognosis, and CTCs can be used in a real-time tumor biopsy for designing individually tailored therapy against CRC.

引用

页码：340 / 347

页数：8

共 83 条

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