Chronic vasopeptidase inhibition normalizes diabetic endothelial dysfunction

被引：20

作者：

Schäfer, S ^{[1
]}

Steioff, K ^{[1
]}

Linz, W ^{[1
]}

Bleich, M ^{[1
]}

Busch, AE ^{[1
]}

Löhn, M ^{[1
]}

机构：

[1] Aventis Pharma Deutschland GmbH, Dis Grp Cardiovasc Dis, D-65926 Frankfurt, Germany

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 484卷 / 2-3期

关键词：

Zucker diabetic fatty rat; diabetic vasculopathy; vasopeptidase inhibition;

D O I：

10.1016/j.ejphar.2003.11.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Type 2 diabetes mellitus is a major cause of vascular morbidity but animal models for this disease have not been adequately characterized. We demonstrate that endothelial dysfunction is present in the Zucker diabetic fatty (ZDF) rat. Vasopeptidase inhibition with AVE7688 (7-[[(2S)-2-(acetylthio)-1-oxo-3-methylpropyl]amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxo-(4S,7S,12bR)-pyrido[2,1-a][2]benzazepine-4-carboxic acid), 45 mg/kg/day in chow for 6 weeks, normalized acetylcholine mediated relaxation of mesenteric artery rings. Thus, chronic vasopeptidase inhibition may prevent vascular complications related to type 2 diabetes mellitus. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：361 / 362

页数：2

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