Diagnostic accuracy of procalcitonin and in patients with acute kidney injury

被引:31
作者
Takahashi, Gaku [1 ]
Shibata, Shigehiro [1 ]
Fukui, Yasuo [2 ]
Okamura, Yoshikazu [3 ]
Inoue, Yoshihiro [1 ]
机构
[1] Iwate Med Univ, Dept Crit Care Med, Morioka, Iwate, Japan
[2] Kochi Hlth Sci Ctr, Dept Surg Gastroenterol, Kochi, Japan
[3] LSI Medience Corp, Tokyo, Japan
关键词
Acute kidney injury; Biomarker; Diagnosis; Infection; Presepsin; Procalcitonin; DISSEMINATED INTRAVASCULAR COAGULATION; EMERGENCY-DEPARTMENT; HUMAN MONOCYTES; SOLUBLE CD14; PRESEPSIN; SEPSIS; MULTICENTER; INFECTION; DISEASE; MODULATION;
D O I
10.1016/j.diagmicrobio.2016.07.015
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Procalcitonin (PCT) and presepsin (PSEP) are sepsis markers, but their diagnostic accuracy may be compromised in acute kidney injury (AICI). We evaluated their diagnostic accuracy in patients with/without AKI. This retrospective study comprised 91 patients with at least one criterion of systematic inflammatory response syndrome. AM markers plasma neutrophil gelatinase-associated lipocalin (NGAL), plasma cystatin C (CysC), and estimated glomerular filtration rate (eGFR) were measured upon hospital admission and on days 1, 3, 5, and 7. Patients were divided into non-AKI and AKI groups. APACHE II severity scores were determined. PCT and PSEP levels were increased significantly in non-AKI and AKI patients with infection. NGAL, CysC, and eGFR in patients with infection were associated with PCT, PSEP, and APACHE II score, and levels of PCT and PSEP were correlated significantly with disease severity. PCT and PSEP are useful markers of bacterial infections in AKI but different thresholds should be applied. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:205 / 210
页数:6
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