Mono- and Dimeric Xanthones with Anti-Glioma and Anti-Inflammatory Activities from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722

被引：13

作者：

Chen, Senhua ^{[1
,2
]}

Guo, Heng ^{[1
,2
]}

Jiang, Minghua ^{[1
,2
]}

Wu, Qilin ^{[1
,2
]}

Li, Jing ^{[1
,2
]}

Shen, Hongjie ^{[1
,2
]}

Liu, Lan ^{[1
,2
,3
,4
]}

机构：

[1] Sun Yat Sen Univ, Sch Marine Sci, Zhuhai 519082, Peoples R China

[2] Southern Lab Ocean Sci & Engn, Zhuhai 519082, Peoples R China

[3] Guangdong Prov Key Lab Marine Resources & Coastal, Zhuhai 519082, Peoples R China

[4] Minist Educ, Pearl River Estuary Marine Ecosyst Res Stn, Zhuhai 519082, Peoples R China

来源：

MARINE DRUGS | 2022年 / 20卷 / 01期

基金：

中国国家自然科学基金;

关键词：

xanthones; ascidian-derived fungus; Diaporthe sp; anti-glioma activity; DERIVATIVES;

D O I：

10.3390/md20010051

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven new xanthones, diaporthones A-G (1-7), together with 13 known analogues, including five mono- (8-14) and six dimeric xanthones (15-20), were obtained from the ascidian-derived fungus Diaporthe sp. SYSU-MS4722. Their planar structures were established by extensive spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HR-ESIMS). The absolute configurations of 1-7 were clearly identified by X-ray crystallographic analysis and calculation of the ECD Spectra. Compounds 15-20 showed significant anti-inflammatory activity with IC50 values between 6.3 and 8.0 mu M. In addition, dimeric xanthones (15-20) showed selective cytotoxicity against T98G cell lines with IC50 values ranging from 19.5 to 78.0 mu M.

引用

页数：14

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