Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

被引：416

作者：

Hojman, Pernille ^{[1
,2
]}

Gehl, Julie ^{[3
]}

Christensen, Jesper F. ^{[1
,2
]}

Pedersen, Bente K. ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Rigshosp, Fac Hlth Sci, CIM, Copenhagen, Denmark

[2] Univ Copenhagen, Rigshosp, Fac Hlth Sci, Ctr Phys Act Res CFAS, Copenhagen, Denmark

[3] Copenhagen Univ Hosp, Dept Oncol, Herlev, Denmark

来源：

CELL METABOLISM | 2018年 / 27卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

NATURAL-KILLER-CELLS; PHYSICAL-ACTIVITY; BREAST-CANCER; PROSTATE-CANCER; SKELETAL-MUSCLE; POSTMENOPAUSAL WOMEN; AEROBIC EXERCISE; ADIPOSE-TISSUE; TUMOR-GROWTH; ASSOCIATION;

D O I：

10.1016/j.cmet.2017.09.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The benefits of exercise training for cancer patients are becoming increasingly evident. Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth. Here we provide the status of the current molecular understanding of the effect of exercise on cancer. We propose that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy. These findings have wide-ranging societal implications, as this understanding may lead to changes in cancer treatment strategies.

引用

页码：10 / 21

页数：12

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