Aspirin Desensitization in Acute Coronary Syndrome and Concurrent Aspirin Hypersensitivity; A Case report from Saudi Arabia

Background: Aspirin is one of the most widely prescribed drugs in clinical practice. Patients with ischemic heart disease need prolonged therapy with this antiplatelet. Patients with history of ASA hypersensitivity are usually denied receiving this treatment. Methods: 6-steps ASA desensitization procedure was performed on a patient with asthma and ASA hypersensitivity who presented with acute coronary syndrome, after failure of alternative monoantiplatelet therapy. Results: The patient tolerated the desensitization procedure successfully with no adverse outcomes. He is currently maintained on daily aspirin and clopidogrel with no further hypersensitivity reactions or cardiac events. Conclusion: This report describes the first ASA desensitization procedure in our institution. ASA desensitization is generally safe, effective, and well tolerated procedure.