Low oxygen stimulates the immune system

被引：10

作者：

Maltzman, J. S. ^{[1
]}

Haase, V. H. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Med, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA

来源：

KIDNEY INTERNATIONAL | 2008年 / 73卷 / 07期

关键词：

D O I：

10.1038/ki.2008.15

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus they provide a novel mechanistic link between hypoxia/ischemia and the activation of the immune system in the kidney.

引用

页码：797 / 799

页数：3

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