Efficient and Convenient Synthesis of N3-(Acyloxymethyl)dihydropyrimidinones by a One-Pot Two-Step Method

被引：3

作者：

Quan, Zheng-Jun ^{[1
,2
]}

Ren, Rong-Guo

Da, Yu-Xia

Zhang, Zhang

Wang, Xi-Cun ^{[1
,2
]}

机构：

[1] Minist Educ, Key Lab Ecoenvironm Related Polymer Mat, Beijing, Peoples R China

[2] NW Normal Univ, Coll Chem & Chem Engn, Gansu Key Lab Polymer Mat, Lanzhou 730070, Gansu, Peoples R China

来源：

LETTERS IN ORGANIC CHEMISTRY | 2011年 / 8卷 / 03期

关键词：

N3-(Acetoxymethyl)dihydropyrimidinones; N3-(benzoyloxymethyl)dihydropyrimidinones; 3,4-dihydropyrimidinones; Biginelli compounds; one-pot reaction; BIGINELLI-COMPOUNDS; SOLID-PHASE; ACCESS; AGENT;

D O I：

10.2174/157017811795038458

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3,4-Dihydropyrimidinones modified with N3-(acetoxymethyl) and (aroyloxymethyl) groups can be regioselectively obtained in good yields by reactions of 3,4-dihydropyrimidinones with paraformaldehyde and substituted benzoic acids/acetic acid, by a one-pot two-step strategy in the presence of chlorotrimethylsilane. The advantages of this method are the simple procedure, the high regioselectivity of the products, shorter reaction time and the mild reaction conditions. Additionally, this method directly uses acid as acylation reagents and needs not acid anhydride or acyl chloride.

引用

页码：188 / 192

页数：5

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