Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer

被引：65

作者：

Carneiro, F. ^{[1
,2
,3
]}

Oliveira, C. ^{[1
,2
]}

Suriano, G. ^{[1
,2
]}

Seruca, R. ^{[1
,2
]}

机构：

[1] Univ Porto, Inst Mol Pathol & Immunol, P-4100 Oporto, Portugal

[2] Univ Porto, Fac Med, P-4100 Oporto, Portugal

[3] Hosp S Joao Porto, Dept Pathol, Oporto, Portugal

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2008年 / 61卷 / 01期

关键词：

D O I：

10.1136/jcp.2006.043679

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gastric cancer is one of the major causes of cancer-related death worldwide. Familial clustering is observed in about 10% of cases; 1-3% of cases are hereditary. In the latter group, a syndrome which has been well characterised is hereditary diffuse gastric cancer; this is specifically associated with CDH1 (E-cadherin) germline mutations in about 30% of families. In this article, the state of the art of familial gastric cancer regarding the clinical, molecular and pathology features is reviewed, as well as the practical aspects for a correct diagnosis and clinical management.

引用

页码：25 / 30

页数：6

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