Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer

被引：65
作者：
Carneiro, F. [1 ,2 ,3 ]
Oliveira, C. [1 ,2 ]
Suriano, G. [1 ,2 ]
Seruca, R. [1 ,2 ]
机构：
[1] Univ Porto, Inst Mol Pathol & Immunol, P-4100 Oporto, Portugal
[2] Univ Porto, Fac Med, P-4100 Oporto, Portugal
[3] Hosp S Joao Porto, Dept Pathol, Oporto, Portugal
来源：
JOURNAL OF CLINICAL PATHOLOGY | 2008年 / 61卷 / 01期
关键词：
D O I：
10.1136/jcp.2006.043679
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Gastric cancer is one of the major causes of cancer-related death worldwide. Familial clustering is observed in about 10% of cases; 1-3% of cases are hereditary. In the latter group, a syndrome which has been well characterised is hereditary diffuse gastric cancer; this is specifically associated with CDH1 (E-cadherin) germline mutations in about 30% of families. In this article, the state of the art of familial gastric cancer regarding the clinical, molecular and pathology features is reviewed, as well as the practical aspects for a correct diagnosis and clinical management.
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收藏
页码：25 / 30
页数：6
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