Explaining the bias in the 23S rRNA gene mutations associated with clarithromycin resistance in clinical isolates of Helicobacter pylori

被引：48
作者：
Debets-Ossenkopp, YJ
Brinkman, AB
Kuipers, EJ
Vandenbroucke-Grauls, CMJE
Kusters, JG
机构：
[1] Free Univ Amsterdam Hosp, Dept Clin Microbiol & Infect Control, NL-1007 MB Amsterdam, Netherlands
[2] Free Univ Amsterdam Hosp, Dept Gastroenterol, NL-1007 MB Amsterdam, Netherlands
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 10期
关键词：
D O I：
10.1128/AAC.42.10.2749
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H. pylori isolates are the mutations from A-2142 to G and A-2143 to G in the 23S rRNA gene. The bias in the 23S rRNA gene mutations conferring clarithromycin resistance mag result from the higher MIC, stability of resistance, and growth rate found for the strains with the above-mentioned mutations.
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页码：2749 / 2751
页数：3
相关论文
共 14 条
[1]  
Ausubel FA, 1995, CURRENT PROTOCOLS MO
[2]  
DebetsOssenkopp YJ, 1996, FEMS MICROBIOL LETT, V142, P37, DOI 10.1016/0378-1097(96)00239-X
[3]   Macrolide resistance in Helicobacter pylori: Mechanism and stability in strains from clarithromycin-treated patients [J].
Hulten, K ;
Gibreel, A ;
Skold, O ;
Engstrand, L .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) :2550-2553
[4]  
Malfertheiner P, 1997, GUT, V41, P8
[5]  
MARSHALL BJ, 1988, LANCET, V2, P1437
[6]   GENETIC-BASIS OF MACROLIDE RESISTANCE IN MYCOBACTERIUM-AVIUM ISOLATED FROM PATIENTS WITH DISSEMINATED DISEASE [J].
NASH, KA ;
INDERLIED, CB .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (12) :2625-2630
[7]  
Shimada A, 1996, Methods Mol Biol, V57, P157
[8]   A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori [J].
Stone, GG ;
Shortridge, D ;
Versalovic, J ;
Beyer, J ;
Flamm, RK ;
Graham, DY ;
Ghoneim, AT ;
Tanaka, SK .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :712-714
[9]   Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations [J].
Taylor, DE ;
Ge, ZM ;
Purych, D ;
Lo, T ;
Hiratsuka, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (12) :2621-2628
[10]   Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori [J].
Versalovic, J ;
Shortridge, D ;
Kibler, K ;
Griffy, MV ;
Beyer, J ;
Flamm, RK ;
Tanaka, SK ;
Graham, DY ;
Go, MF .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (02) :477-480
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