A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs

被引：28
作者：
Eguchi, Takanori [1 ,2 ]
Taha, Eman Ahmed [1 ,3 ,4 ]
Calderwood, Stuart K. [5 ]
Ono, Kisho [6 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Dent Pharmacol, Okayama 7008525, Japan
[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Adv Res Ctr Oral & Craniofacial Sci, Okayama 7008525, Japan
[3] Okayama Univ, Grad Sch Nat Sci & Technol, Dept Med Bioengn, Okayama 7008530, Japan
[4] Ain Shams Univ, Fac Sci, Dept Biochem, Cairo 11566, Egypt
[5] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Radiat Oncol, Boston, MA 02215 USA
[6] Okayama Univ Hosp, Dept Oral & Maxillofacial Surg, Okayama 7000914, Japan
来源：
BIOLOGY-BASEL | 2020年 / 9卷 / 03期
关键词：
extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; resistance-associated secretory phenotype (RASP); hypoxia; acidosis; tumor immunology; HEAT-SHOCK PROTEINS; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR VESICLES; TUMOR MICROENVIRONMENT; P-GLYCOPROTEIN; BREAST-CANCER; STEM-CELLS; MICROVESICLES PROMOTE; INDUCE APOPTOSIS; MEDIATE TRANSFER;
D O I：
10.3390/biology9030047
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Extracellular vesicles (EVs), such as exosomes or oncosomes, often carry oncogenic molecules derived from tumor cells. In addition, accumulating evidence indicates that tumor cells can eject anti-cancer drugs such as chemotherapeutics and targeted drugs within EVs, a novel mechanism of drug resistance. The EV-releasing drug resistance phenotype is often coupled with cellular dedifferentiation and transformation in cells undergoing epithelial-mesenchymal transition (EMT), and the adoption of a cancer stem cell phenotype. The release of EVs is also involved in immunosuppression. Herein, we address different aspects by which EVs modulate the tumor microenvironment to become resistant to anticancer and antibody-based drugs, as well as the concept of the resistance-associated secretory phenotype (RASP).
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页数：22
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