Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties

被引：7

作者：

Behzadi, Soheila Asadpour ^{[1
]}

Sheikhhosseini, Enayatollah ^{[1
]}

Ahmadi, Sayed Ali ^{[1
]}

Ghazanfari, Dadkhoda ^{[1
]}

Akhgar, Mohammadreza ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Kerman Branch, Kerman, Iran

来源：

HETEROCYCLIC COMMUNICATIONS | 2020年 / 26卷 / 01期

关键词：

tetracoumarin; 4-hydroxycoumarin; aqueous media; ethylene ether spacer; biological activity; COUMARIN DERIVATIVES; BISCOUMARIN; SOLVENT; WATER; 4-HYDROXYCOUMARIN; INHIBITORS; CATALYST; SCAFFOLD;

D O I：

10.1515/hc-2020-0009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel tetracoumarin derivatives (3a-f) were prepared using the reaction of ether functionalized dibenzaldehyde with 4-hydroxycoumarin in the presence of sodium acetate. The structure of compounds was validated by IR, NMR, and CHN analyzes. Antimicrobial (antibacterial and antifungal) activity was studied on the basis of the minimum bactericidal concentration, minimum inhibitory concentration and inhibitory zone diameter. Favorable biological activity was found in compound 3f.

引用

页码：60 / 67

页数：8

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