An array of possibilities for the study of autoimmunity

被引:69
作者
Fathman, CG [1 ]
Soares, L
Chan, SM
Utz, PJ
机构
[1] Stanford Univ, Sch Med, Dept Med, Div Rheumatol & Immunol, Stanford, CA 94305 USA
[2] IBMP, Curitiba, Parana, Brazil
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nature03726
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Since the completion of the sequencing of the human genome, scientific focus has shifted from studying genes to analysing the much larger number of proteins encoded by them. Several proteins can be generated from a single gene depending on how the genetic information is read ( transcribed) and how the resultant protein is modified following translation (post-translational modification). Genomic and proteomic technologies are already providing useful information about autoimmune disease, and they are likely to lead to important discoveries within the next decade.
引用
收藏
页码:605 / 611
页数:7
相关论文
共 58 条
  • [21] The transcriptional program in the response of human fibroblasts to serum
    Iyer, VR
    Eisen, MB
    Ross, DT
    Schuler, G
    Moore, T
    Lee, JCF
    Trent, JM
    Staudt, LM
    Hudson, J
    Boguski, MS
    Lashkari, D
    Shalon, D
    Botstein, D
    Brown, PO
    [J]. SCIENCE, 1999, 283 (5398) : 83 - 87
  • [22] Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays
    Johnson, JM
    Castle, J
    Garrett-Engele, P
    Kan, ZY
    Loerch, PM
    Armour, CD
    Santos, R
    Schadt, EE
    Stoughton, R
    Shoemaker, DD
    [J]. SCIENCE, 2003, 302 (5653) : 2141 - 2144
  • [23] Joos TO, 2000, ELECTROPHORESIS, V21, P2641, DOI 10.1002/1522-2683(20000701)21:13<2641::AID-ELPS2641>3.3.CO
  • [24] 2-X
  • [25] Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-β1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active disease
    Kader, HA
    Tchernev, VT
    Satyaraj, E
    Lejnine, S
    Kotler, G
    Kingsmore, SF
    Patel, DD
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2005, 100 (02) : 414 - 423
  • [26] Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
    Karpuj, MV
    Becher, MW
    Springer, JE
    Chabas, D
    Youssef, S
    Pedotti, R
    Mitchell, D
    Steinman, L
    [J]. NATURE MEDICINE, 2002, 8 (02) : 143 - 149
  • [27] A map of the interactome network of the metazoan C-elegans
    Li, SM
    Armstrong, CM
    Bertin, N
    Ge, H
    Milstein, S
    Boxem, M
    Vidalain, PO
    Han, JDJ
    Chesneau, A
    Hao, T
    Goldberg, DS
    Li, N
    Martinez, M
    Rual, JF
    Lamesch, P
    Xu, L
    Tewari, M
    Wong, SL
    Zhang, LV
    Berriz, GF
    Jacotot, L
    Vaglio, P
    Reboul, J
    Hirozane-Kishikawa, T
    Li, QR
    Gabel, HW
    Elewa, A
    Baumgartner, B
    Rose, DJ
    Yu, HY
    Bosak, S
    Sequerra, R
    Fraser, A
    Mango, SE
    Saxton, WM
    Strome, S
    van den Heuvel, S
    Piano, F
    Vandenhaute, J
    Sardet, C
    Gerstein, M
    Doucette-Stamm, L
    Gunsalus, KC
    Harper, JW
    Cusick, ME
    Roth, FP
    Hill, DE
    Vidal, M
    [J]. SCIENCE, 2004, 303 (5657) : 540 - 543
  • [28] Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis
    Liao, H
    Wu, J
    Kuhn, E
    Chin, W
    Chang, B
    Jones, MD
    O'Neil, S
    Clauser, KR
    Karl, J
    Hasler, F
    Roubenoff, R
    Zolg, W
    Guild, BC
    [J]. ARTHRITIS AND RHEUMATISM, 2004, 50 (12): : 3792 - 3803
  • [29] Protein microarrays: Meeting analytical challenges for clinical applications
    Liotta, LA
    Espina, V
    Mehta, AI
    Calvert, V
    Rosenblatt, K
    Geho, D
    Munson, PJ
    Young, L
    Wulfkuhle, J
    Petricoin, EF
    [J]. CANCER CELL, 2003, 3 (04) : 317 - 325
  • [30] Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    Lock, C
    Hermans, G
    Pedotti, R
    Brendolan, A
    Schadt, E
    Garren, H
    Langer-Gould, A
    Strober, S
    Cannella, B
    Allard, J
    Klonowski, P
    Austin, A
    Lad, N
    Kaminski, N
    Galli, SJ
    Oksenberg, JR
    Raine, CS
    Heller, R
    Steinman, L
    [J]. NATURE MEDICINE, 2002, 8 (05) : 500 - 508