The objectives of this prospective case-control study were to determine liver stiffness (LSM) by transient elastography (TE) in children with newly diagnosed chronic liver disease (CLD) and to find out normal values in healthy Indian children. Two groups (A: 50 CLD who underwent liver biopsy and B: 50 healthy) aged 5-18 years were recruited prospectively. Liver biopsies were scored as per Metavir scoring and compared with TE. The median age of 100 recruited children was 13.6 years. In group B, normal LSM was 4.9 (2.5-7.3) kPa with significantly higher LSM in adolescent males (5.6 (4.1-7.3) kPa) as compared with females (4.3 (3.7-4.9) kPa), p = 0.001. In group A, TE was excellent in discriminating significant fibrosis (>= F2) (P = 0.001) at a cut-off value of 10.6 kPa with area under receiver operating characteristic curve of 0.96. Metavir fibrosis stage (beta = 0.611; R2 = 0.586) and age (beta = 0.230; R2 = 0.586) were independent variables associated with higher LSM in stepwise multiple logistic regression analysis. Conclusions: TE is an excellent non-invasive tool to assess significant liver fibrosis and can be used as an alternative to liver biopsy. Normative value of TE in adolescent males is higher than in females.
机构:
Bambino Gesu Childrens Hosp & Res Inst, Liver Unit, Rome, ItalyCleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA
Alisi, Anna
Lopez, Rocio
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机构:Cleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA
Lopez, Rocio
Pinzani, Massimo
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机构:
Univ Florence, Dept Internal Med, Ctr Res High Educ & Transfer DENO, Florence, ItalyCleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA
Pinzani, Massimo
Feldstein, Ariel E.
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Univ Calif San Diego, Rady Childrens Hosp, Dept Pediat Gastroenterol, San Diego, CA 92103 USACleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA
Feldstein, Ariel E.
Nobili, Valerio
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机构:
Bambino Gesu Childrens Hosp & Res Inst, Liver Unit, Rome, ItalyCleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA
机构:
Bambino Gesu Childrens Hosp & Res Inst, Liver Unit, Rome, ItalyCleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA
Alisi, Anna
Lopez, Rocio
论文数: 0引用数: 0
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机构:Cleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA
Lopez, Rocio
Pinzani, Massimo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Florence, Dept Internal Med, Ctr Res High Educ & Transfer DENO, Florence, ItalyCleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA
Pinzani, Massimo
Feldstein, Ariel E.
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h-index: 0
机构:
Univ Calif San Diego, Rady Childrens Hosp, Dept Pediat Gastroenterol, San Diego, CA 92103 USACleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA
Feldstein, Ariel E.
Nobili, Valerio
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h-index: 0
机构:
Bambino Gesu Childrens Hosp & Res Inst, Liver Unit, Rome, ItalyCleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA