Utility and accuracy of transient elastography in determining liver fibrosis: a case-control study

被引:16
作者
Jain, Vikas [1 ]
Poddar, Ujjal [1 ]
Negi, Tajwar Singh [2 ]
Saraswat, Vivek A. [2 ]
Krishnani, Narendra [3 ]
Yachha, Surender Kumar [1 ]
Srivastava, Anshu [1 ]
机构
[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Pediat Gastroenterol, Raebareli Rd, Lucknow 226014, Uttar Pradesh, India
[2] Sanjay Gandhi Postgrad Inst Med Sci, Dept Gastroenterol, Lucknow, Uttar Pradesh, India
[3] Sanjay Gandhi Postgrad Inst Med Sci, Dept Pathol, Lucknow, Uttar Pradesh, India
关键词
Transient elastography; Chronic liver disease; Liver fibrosis; Children; STIFFNESS MEASUREMENT; HEPATITIS-C; DIAGNOSIS; CHILDREN; FEASIBILITY; MANAGEMENT; CIRRHOSIS; BIOPSY; INDEX;
D O I
10.1007/s00431-019-03561-y
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The objectives of this prospective case-control study were to determine liver stiffness (LSM) by transient elastography (TE) in children with newly diagnosed chronic liver disease (CLD) and to find out normal values in healthy Indian children. Two groups (A: 50 CLD who underwent liver biopsy and B: 50 healthy) aged 5-18 years were recruited prospectively. Liver biopsies were scored as per Metavir scoring and compared with TE. The median age of 100 recruited children was 13.6 years. In group B, normal LSM was 4.9 (2.5-7.3) kPa with significantly higher LSM in adolescent males (5.6 (4.1-7.3) kPa) as compared with females (4.3 (3.7-4.9) kPa), p = 0.001. In group A, TE was excellent in discriminating significant fibrosis (>= F2) (P = 0.001) at a cut-off value of 10.6 kPa with area under receiver operating characteristic curve of 0.96. Metavir fibrosis stage (beta = 0.611; R2 = 0.586) and age (beta = 0.230; R2 = 0.586) were independent variables associated with higher LSM in stepwise multiple logistic regression analysis. Conclusions: TE is an excellent non-invasive tool to assess significant liver fibrosis and can be used as an alternative to liver biopsy. Normative value of TE in adolescent males is higher than in females.
引用
收藏
页码:671 / 677
页数:7
相关论文
共 30 条
  • [1] Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease
    Alkhouri, Naim
    Sedki, Emad
    Alisi, Anna
    Lopez, Rocio
    Pinzani, Massimo
    Feldstein, Ariel E.
    Nobili, Valerio
    [J]. LIVER INTERNATIONAL, 2013, 33 (01) : 79 - 85
  • [2] An algorithm for the grading of activity in chronic hepatitis C
    Bedossa, P
    Poynard, T
    [J]. HEPATOLOGY, 1996, 24 (02) : 289 - 293
  • [3] Practices of liver biopsy in France: Results of a prospective nationwide survey
    Cadranel, JF
    Rufat, P
    Degos, F
    [J]. HEPATOLOGY, 2000, 32 (03) : 477 - 481
  • [4] Transient elastography for diagnosis of advanced fibrosis and portal hypertension in patients with hepatitis C recurrence after liver transplantation
    Carrion, Jose A.
    Navasa, Miquel
    Bosch, Jaume
    Bruguera, Miquel
    Gilabert, Rosa
    Forns, Xavier
    [J]. LIVER TRANSPLANTATION, 2006, 12 (12) : 1791 - 1798
  • [5] Prospective comparison of transient elastography, fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C
    Castéra, L
    Vergniol, J
    Foucher, J
    Le Bail, B
    Chanteloup, E
    Haaser, M
    Darriet, M
    Couzigou, P
    De Lédinghen, V
    [J]. GASTROENTEROLOGY, 2005, 128 (02) : 343 - 350
  • [6] Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan
    Cho, Yuki
    Tokuhara, Daisuke
    Morikawa, Hiroyasu
    Kuwae, Yuko
    Hayashi, Eri
    Hirose, Masakazu
    Hamazaki, Takashi
    Tanaka, Akemi
    Kawamura, Tomoyuki
    Kawada, Norifumi
    Shintaku, Haruo
    [J]. PLOS ONE, 2015, 10 (09):
  • [7] Assessment of biliary fibrosis by transient elastography in patients with PBC and PSC
    Corpechot, C
    El Naggar, A
    Poujol-Robert, A
    Ziol, M
    Wendum, D
    Chazouillères, O
    De Lédinghen, V
    Dhumeaux, D
    Marcellin, P
    Beaugrand, M
    Poupon, R
    [J]. HEPATOLOGY, 2006, 43 (05) : 1118 - 1124
  • [8] Liver stiffness measurement in children using FibroScan:: Feasibility study and comparison with fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy
    de Ledinghen, Victor
    Le Bail, Brigitte
    Rebouissoux, Laurent
    Fournier, Celine
    Foucher, Juliette
    Miette, Veronique
    Castera, Laurent
    Sandrin, Laurent
    Merrouche, Wassil
    Lavrand, Frederic
    Lamireau, Thierry
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2007, 45 (04) : 443 - 450
  • [9] Feasibility study and control values of transient elastography in healthy children
    Engelmann, Guido
    Gebhardt, Caroline
    Wenning, Daniel
    Wuehl, Elke
    Hoffmann, Georg F.
    Selmi, Buket
    Grulich-Henn, Juergen
    Schenk, Jens Peter
    Teufel, Ulrike
    [J]. EUROPEAN JOURNAL OF PEDIATRICS, 2012, 171 (02) : 353 - 360
  • [10] Transient Elastography Is a Useful Noninvasive Tool for the Evaluation of Fibrosis in Paediatric Chronic Liver Disease
    Fitzpatrick, Emer
    Quaglia, Alberto
    Vimalesvaran, Sunitha
    Basso, Maria Sole
    Dhawan, Anil
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2013, 56 (01) : 72 - 76