Gene-environment interactions in human diseases

被引：768
作者：
Hunter, DJ
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA
来源：
NATURE REVIEWS GENETICS | 2005年 / 6卷 / 04期
关键词：
D O I：
10.1038/nrg1578
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Studies of gene-environment interactions aim to describe how genetic and environmental factors jointly influence the risk of developing a human disease. Gene-environment interactions can be described by using several models, which take into account the various ways in which genetic effects can be modified by environmental exposures, the number of levels of these exposures and the model on which the genetic effects are based. Choice of study design, sample size and genotyping technology influence the analysis and interpretation of observed gene-environment interactions. Current systems for reporting epidemiological studies make it difficult to assess whether the observed interactions are reproducible, so suggestions are made for improvements in this area.
引用
收藏
页码：287 / 298
页数：12
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