Ghrelin and Obesity: Identifying Gaps and Dispelling Myths. A Reappraisal

被引：63
作者：
Makris, Marinos C. [1 ,2 ]
Alexandrou, Andreas [3 ]
Papatsoutsos, Efstathios G. [4 ]
Malietzis, George [5 ]
Tsilimigras, Diamantis I. [3 ]
Guerron, Alfredo D. [6 ]
Moris, Demetrios [6 ]
机构：
[1] G Gennimatas Gen Hosp Athens, Surg Dept 1, Athens, Greece
[2] Alpha Inst Biomed Sci, Athens, Greece
[3] Laikon Gen Hosp, Dept Surg 1, Athens, Greece
[4] St Marien Hosp, Dept Gen Surg, Buer, Germany
[5] St Marks Hosp, Dept Colorectal Surg, London, England
[6] Duke Univ, Dept Surg, Div Metab & Weight Loss Surg, Durham, NC USA
来源：
IN VIVO | 2017年 / 31卷 / 06期
关键词：
Ghrelin; obesity; appetite; hormone levels; diet; bariatric surgery; review; LAPAROSCOPIC SLEEVE GASTRECTOMY; GASTRIC BYPASS-SURGERY; WEIGHT-LOSS; GUT HORMONES; LEPTIN; OVERWEIGHT; DISORDERS; DISEASE; HUMANS;
D O I：
10.21873/invivo.11168
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The etiology of obesity is complex. Environmental and genetic causes have been implicated in the development of this disease. Ghrelin is a hormone known to stimulate appetite. There are numerous possible actions through which ghrelin exerts its effect in the body: a) Overproduction of ghrelin, b) reduced ghrelin following meals, and c) increased receptor sensitivity to ghrelin action. Sleeve gastrectomy, a bariatric procedure, leads to reduction of ghrelin levels and subsequently to weight loss. However, there are many limitations to measurement of the fasting plasma level of the active form of ghrelin. The establishment of the exact correlation between ghrelin, appetite and obesity could be vital for the fight against obesity.
引用
收藏
页码：1047 / 1050
页数：4
相关论文
共 27 条
[1]   Morphology, Localization, and Patterns of Ghrelin-producing Cells in Stomachs of a Morbidly Obese Population [J].
Abdemur, Abraham ;
Slone, Johnathan ;
Berho, Mariana ;
Gianos, Melissa ;
Szomstein, Samuel ;
Rosenthal, Raul J. .
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES, 2014, 24 (02) :122-126
[2]   The Impact of Laparoscopic Sleeve Gastrectomy on Plasma Ghrelin Levels: a Systematic Review [J].
Anderson, Blaire ;
Switzer, Noah J. ;
Almamar, Ahmad ;
Shi, Xinzhe ;
Birch, Daniel W. ;
Karmali, Shahzeer .
OBESITY SURGERY, 2013, 23 (09) :1476-1480
[3]   Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans [J].
Arvat, E ;
Di Vito, L ;
Broglio, F ;
Papotti, M ;
Muccioli, G ;
Dieguez, C ;
Casanueva, FF ;
Deghenghi, R ;
Camanni, F ;
Ghigo, E .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2000, 23 (08) :493-495
[4]  
Billington CJ, 2000, ARCH INTERN MED, V160, P898, DOI 10.1001/archinte.160.7.898
[5]   Scintigraphic Evaluation of Gastric Emptying in Obese Patients Submitted to Sleeve Gastrectomy Compared to Normal Subjects [J].
Braghetto, Italo ;
Davanzo, Cristobal ;
Korn, Owen ;
Csendes, Attila ;
Valladares, Hector ;
Herrera, Eduardo ;
Gonzalez, Patricio ;
Papapietro, Karin .
OBESITY SURGERY, 2009, 19 (11) :1515-1521
[6]   Actions and therapeutic pathways of ghrelin for gastrointestinal disorders [J].
Camilleri, Michael ;
Papathanasopoulos, Athanasios ;
Odunsi, Suwebatu T. .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2009, 6 (06) :343-352
[7]   Role of Ghrelin in the Pathophysiology of Gastrointestinal Disease [J].
Cheung, Cynthia K. ;
Wu, Justin Che-Yuen .
GUT AND LIVER, 2013, 7 (05) :505-512
[8]   Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. [J].
Cummings, DE ;
Weigle, DS ;
Frayo, RS ;
Breen, PA ;
Ma, MK ;
Dellinger, EP ;
Purnell, JQ .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (21) :1623-1630
[9]   Alterations in Gut Hormones After Laparoscopic Sleeve Gastrectomy A Prospective Clinical and Laboratory Investigational Study [J].
Dimitriadis, Efstathios ;
Daskalakis, Markos ;
Kampa, Marilena ;
Peppe, Anastasia ;
Papadakis, John A. ;
Melissas, John .
ANNALS OF SURGERY, 2013, 257 (04) :647-654
[10]   Ghrelin: a gut-brain hormone: Effect of gastric bypass surgery [J].
Geloneze, B ;
Tambascia, MA ;
Pilla, VF ;
Geloneze, SR ;
Repetto, EM ;
Pareja, JC .
OBESITY SURGERY, 2003, 13 (01) :17-22
123