Investigational antiviral drugs for the treatment of COVID-19

被引：0

作者：

Vegivinti, C. T. R. ^{[1
]}

Assi, M. ^{[2
]}

Talwani, R. ^{[3
]}

Koblizek, V ^{[4
,5
]}

Burke, K. ^{[6
]}

Temesgen, Z. ^{[7
]}

机构：

[1] Manipal Acad Higher Educ MAHE, Kasturba Med Coll, Dept Gen Med, Manipal, Karnataka, India

[2] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA USA

[3] Univ Maryland, Div Infect Dis, Baltimore, MD 21201 USA

[4] Charles Univ Prague, Univ Hosp Hradec Kralove, Prague, Czech Republic

[5] Charles Univ Prague, Fac Med, Prague, Czech Republic

[6] Wolters Kluwer, Clin Effectiveness, Indianapolis, IN USA

[7] Mayo Clin & Mayo Fdn, Div Infect Dis, Rochester, MN USA

来源：

DRUGS OF THE FUTURE | 2021年 / 46卷 / 09期

基金：

美国国家卫生研究院;

关键词：

COVID-19; SARS-CoV-2; Remdesivir; Hydroxychloroquine; Lopinavir/ritonavir; Ribavirin; Ivermectin; Favipiravir; Umifenovir; Camostat; Nafamostat Nitazoxanide; DAS-181; RESPIRATORY SYNDROME CORONAVIRUS; SIALIDASE FUSION PROTEIN; NAFAMOSTAT MESILATE; INTERFERON-THERAPY; RIBAVIRIN; IVERMECTIN; INHIBITOR; DAS181; RITONAVIR; INFECTION;

D O I：

10.1358/dof.2021.46.9.3293585

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A large number of candidate drugs are undergoing evaluation for their potential to limit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication. Clinical trial data are slowly emerging for several of these agents. We provide a review of candidate antiviral agents registered in ClinicalTrials.gov , which have clinical efficacy data, provide the rationale for their consideration for this purpose, and summarize available data on their efficacy and safety.

引用

页码：697 / 710

页数：14

共 119 条

[1] Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease [J].

Agostini, Maria L. ;

Andres, Erica L. ;

Sims, Amy C. ;

Graham, Rachel L. ;

Sheahan, Timothy P. ;

Lu, Xiaotao ;

Smith, Everett Clinton ;

Case, James Brett ;

Feng, Joy Y. ;

Jordan, Robert ;

Ray, Adrian S. ;

Cihlar, Tomas ;

Siegel, Dustin ;

Mackman, Richard L. ;

Clarke, Michael O. ;

Baric, Ralph S. ;

Denison, Mark R. .

MBIO, 2018, 9 (02)

[2] A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness [J].

Ahmed, Sabeena ;

Karim, Mohammad Mahbubul ;

Ross, Allen G. ;

Hossain, Mohammad Sharif ;

Clemens, John D. ;

Sumiya, Mariya Kibtiya ;

Phru, Ching Swe ;

Rahman, Mustafizur ;

Zaman, Khalequ ;

Somani, Jyoti ;

Yasmin, Rubina ;

Hasnat, Mohammad Abul ;

Kabir, Ahmedul ;

Aziz, Asma Binte ;

Khan, Wasif Ali .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2021, 103 :214-216

[3] Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases [J].

Al-Bari, Md Abdul Alim .

PHARMACOLOGY RESEARCH & PERSPECTIVES, 2017, 5 (01)

[4] Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study [J].

Al-Tawfiq, Jaffar A. ;

Momattin, Hisham ;

Dib, Jean ;

Memish, Ziad A. .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2014, 20 :42-46

[5] Efficacy and Safety of Lopinavir/Ritonavir for Treatment of COVID-19: A Systematic Review and Meta-Analysis [J].

Alhumaid, Saad ;

Al Mutair, Abbas ;

Al Alawi, Zainab ;

Alhmeed, Naif ;

Zaidi, Abdul Rehman Zia ;

Tobaiqy, Mansour .

TROPICAL MEDICINE AND INFECTIOUS DISEASE, 2020, 5 (04)

[6]

[Anonymous], 2020, Clinical management of COVID-19: interim guidance.

[7] Ribavirin and Interferon Therapy for Critically Ill Patients With Middle East Respiratory Syndrome: A Multicenter Observational Study [J].

Arabi, Yaseen M. ;

Shalhoub, Sarah ;

Mandourah, Yasser ;

Al-Hameed, Fahad ;

Al-Omari, Awad ;

Al Qasim, Eman ;

Jose, Jesna ;

Alraddadi, Basem ;

Almotairi, Abdullah ;

Al Khatib, Kasim ;

Abdulmomen, Ahmed ;

Qushmaq, Ismael ;

Sindi, Anees A. ;

Mady, Ahmed ;

Solaiman, Othman ;

Al-Raddadi, Rajaa ;

Maghrabi, Khalid ;

Ragab, Ahmed ;

Al Mekhlafi, Ghaleb A. ;

Balkhy, Hanan H. ;

Al Harthy, Abdulrahman ;

Kharaba, Ayman ;

Gramish, Jawaher A. ;

Al-Aithan, Abdulsalam M. ;

Al-Dawood, Abdulaziz ;

Merson, Laura ;

Hayden, Frederick G. ;

Fowler, Robert .

CLINICAL INFECTIOUS DISEASES, 2020, 70 (09) :1837-1844

[8]

Arevalo AP, 2020, bioRxiv, DOI [10.1101/2020.11.02.363242, 10.1101/2020.11.02.363242, DOI 10.1101/2020.11.02.363242]

[9] Potential of heparin and nafamostat combination therapy for COVID-19 [J].

Asakura, Hidesaku ;

Ogawa, Haruhiko .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020, 18 (06) :1521-1522

[10] Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus [J].

Atif, Mohammed ;

Estrada-Mondragon, Argel ;

Nguyen, Bindi ;

Lynch, Joseph W. ;

Keramidas, Angelo .

PLOS PATHOGENS, 2017, 13 (10)

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