Cobalt-Catalyzed Isocyanide-Based Three-Component Cascade for the Synthesis of Quinazolines

被引：24

作者：

Jiang, Shuai ^{[1
,2
]}

Cao, Wen-Bin ^{[1
,2
]}

Xu, Xiao-Ping ^{[1
,2
,3
]}

Ji, Shun-Jun ^{[1
,2
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

[2] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China

[3] Soochow Univ, Innovat Ctr Chem Sci, Suzhou 215123, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 17期

基金：

中国国家自然科学基金;

关键词：

NITROGEN-HETEROCYCLES; ISONITRILES; CYCLIZATION; TOOLS; SALTS;

D O I：

10.1021/acs.orglett.1c02316

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Co-catalyzed cyclization reaction of isocyanides, azides, and amines to access quinazoline derivatives was described. This protocol features a high atom economy, mild reaction conditions, excellent yields, and a broad substrate scope. This cascade reaction involved three or four C-N bonds and the formation of one or two rings. The quinazolin-4(H)-imines obtained are proven to be versatile intermediates for further valuable transformations. It was also found that the cobalt catalyst could be isolated from the reaction mixture and reused.

引用

页码：6740 / 6744

页数：5

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