Bronchiolitis treated with mechanical ventilation: prognosis factors and outcome in a series of 135 children

.Viral bronchiolitis is usually associated with favorable outcome as regard to mortality. Only few studies reported severe bronchiolitis requiring mechanical ventilation, and respiratory outcome is not well described. Methods. - Therefore, we conducted a retrospective Study in a series of 135 children admitted in a single Pediatric Intensive Care Unit (PICU) over a four year period (1994-1998). All of them were admitted for viral bronchiolitis requiring mechanical ventilation. Results. - At admission, 83% of them were less than three months old. Prematurity at birth was present in 33,3%. Mortality was observed in four cases (2,9%), all premature babies with mechanical ventilation at birth. Univariate analysis showed as main factors associated to mortality: prematurity (P =0,056) and acute respiratory distress syndrome (P =0,01 7). Childhood asthma was observed in 40,4% of children without any associated factor wether at birth or in PICU related to such outcome. Conclusion. - Bronchiolitis associated with mechanical ventilation is particulary observed in very young babies and prematurity is the main factor associated to mortality. Mechanical ventilation seems not to be associated with unfavorable respiratory outcome. Considering physiology and population, non invasive ventilation could be an effective alternative of mechanical ventilation. (c) 2005 Elsevier SAS.