Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from (283.15 to 313.15)K

被引：5

作者：

Guo, Mingxia ^{[1
]}

Yin, Qiuxiang ^{[1
,2
]}

Wang, Chang ^{[1
]}

Huang, Yaohui ^{[1
]}

Li, Yang ^{[1
]}

Zhang, Zaixiang ^{[1
]}

Zhang, Xia ^{[1
]}

Wang, Zhao ^{[1
,2
]}

Zhang, Meijing ^{[1
,2
]}

Zhou, Ling ^{[1
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Coinnovat Ctr Chem & Chem Engn Tianjin, Tianjin 300072, Peoples R China

来源：

CHINESE JOURNAL OF CHEMICAL ENGINEERING | 2017年 / 25卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Metamizol monohydrate; Solubility; Thermodynamic properties; Correlation; MAGNESIUM-DL-ASPARTATE; P-TOLUIC ACID; ORGANIC-SOLVENTS; LIQUID-EQUILIBRIUM; MIXING PROPERTIES; SOLUBILITY; MIXTURES; WATER; FORM;

D O I：

10.1016/j.cjche.2017.03.026

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The thermodynamic properties of metamizol monohydrate in pure solvents (methanol, ethanol, n-propanol and isopropanol) and two binary mixed solvent systems including (methanol + ethanol) and (methanol + isopropanol) were measured from 283.15 K to 313.15 K by gravimetric method under atmospheric pressure thought as 0.1 MPa. The modified Apelblal. equation, the CNI135/R-K equation, the Hybrid model and the NRTL model were used Lo correlate the solubility of metamizol monohydrate, respectively. The resifts show thaL the solubility of metamizol monohydraLe in all the tested solvents increases with the rising Temperature which means that it has temperature dependence. What's more, the effects of components of the binary solvent mixtures on solubility were discussed, it illustrates that the increasing of the molar fraction of methanol gives the system a greater dissolving power. Furthermore, according to the NRTL model, the enthalpy, the Gibbs energy and the entropy of the mixing process were also obtained and discussed. (C) 2017 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved.

引用

页码：1481 / 1491

页数：11

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