Adapting to obesity with adipose tissue inflammation

被引：906

作者：

Reilly, Shannon M. ^{[1
]}

Saltiel, Alan R. ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2017年 / 13卷 / 11期

关键词：

NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; INNATE LYMPHOID-CELLS; NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; TOLL-LIKE RECEPTOR; INSULIN-RESISTANCE; BEIGE FAT; T-CELLS; NLRP3; INFLAMMASOME;

D O I：

10.1038/nrendo.2017.90

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipose tissue not only has an important role in the storage of excess nutrients but also senses nutrient status and regulates energy mobilization. An overall positive energy balance is associated with overnutrition and leads to excessive accumulation of fat in adipocytes. These cells respond by initiating an inflammatory response that, although maladaptive in the long run, might initially be a physiological response to the stresses obesity places on adipose tissue. In this Review, we characterize adipose tissue inflammation and review the current knowledge of what triggers obesity-associated inflammation in adipose tissue. We examine the connection between adipose tissue inflammation and the development of insulin resistance and catecholamine resistance and discuss the ensuing state of metabolic inflexibility. Finally, we review the current and potential new anti-inflammatory treatments for obesity-associated metabolic disease.

引用

页码：633 / 643

页数：11

共 175 条

[31] Interplay between FGF21 and insulin action in the liver regulates metabolism [J].

Emanuelli, Brice ;

Vienberg, Sara G. ;

Smyth, Graham ;

Cheng, Christine ;

Stanford, Kristin I. ;

Arumugam, Manimozhiyan ;

Michael, Mervyn D. ;

Adams, Andrew C. ;

Kharitonenkov, Alexei ;

Kahn, C. Ronald .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (02) :515-527

[32] RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet (Retracted article. See vol. 378, pg. 2441, 2018) [J].

Estruch, Ramon ;

Ros, Emilio ;

Salas-Salvado, Jordi ;

Covas, Maria-Isabel ;

Corella, Dolores ;

Aros, Fernando ;

Gomez-Gracia, Enrique ;

Ruiz-Gutierrez, Valentina ;

Fiol, Miquel ;

Lapetra, Jose ;

Maria Lamuela-Raventos, Rosa ;

Serra-Majem, Lluis ;

Pinto, Xavier ;

Basora, Josep ;

Angel Munoz, Miguel ;

Sorli, Jose V. ;

Alfredo Martinez, Jose ;

Angel Martinez-Gonzalez, Miguel .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (14) :1279-1290

[33] Development of anti-TNF therapy for rheumatoid arthritis [J].

Feldmann, M .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (05) :364-371

[34] Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters [J].

Feuerer, Markus ;

Herrero, Laura ;

Cipolletta, Daniela ;

Naaz, Afia ;

Wong, Jamie ;

Nayer, Ali ;

Lee, Jongsoon ;

Goldfine, Allison B. ;

Benoist, Christophe ;

Shoelson, Steven ;

Mathis, Diane .

NATURE MEDICINE, 2009, 15 (08) :930-U137

[35] Monounsaturated Fatty Acid-Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome-Mediated IL-1β Secretion and Insulin Resistance Despite Obesity [J].

Finucane, Orla M. ;

Lyons, Claire L. ;

Murphy, Aoife M. ;

Reynolds, Clare M. ;

Klinger, Rut ;

Healy, Niamh P. ;

Cooke, Aoife A. ;

Coll, Rebecca C. ;

McAllan, Liam ;

Nilaweera, Kanishka N. ;

O'Reilly, Marcella E. ;

Tierney, Audrey C. ;

Morine, Melissa J. ;

Alcala-Diaz, Juan F. ;

Lopez-Miranda, Jose ;

O'Connor, Darran P. ;

O'Neill, Luke A. ;

McGillicuddy, Fiona C. ;

Roche, Helen M. .

DIABETES, 2015, 64 (06) :2116-2128

[36] Targeted Deletion of Adipocytes by Apoptosis Leads to Adipose Tissue Recruitment of Alternatively Activated M2 Macrophages [J].

Fischer-Posovszky, Pamela ;

Wang, Qiong A. ;

Asterholm, Ingrid Wernstedt ;

Rutkowski, Joseph M. ;

Scherer, Philipp E. .

ENDOCRINOLOGY, 2011, 152 (08) :3074-3081

[37] FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis [J].

Fisher, Ffolliott M. ;

Kleiner, Sandra ;

Douris, Nicholas ;

Fox, Elliott C. ;

Mepani, Rina J. ;

Verdeguer, Francisco ;

Wu, Jun ;

Kharitonenkov, Alexei ;

Flier, Jeffrey S. ;

Maratos-Flier, Eleftheria ;

Spiegelman, Bruce M. .

GENES & DEVELOPMENT, 2012, 26 (03) :271-281

[38] LEPTIN LEVELS REFLECT BODY LIPID-CONTENT IN MICE - EVIDENCE FOR DIET-INDUCED RESISTANCE TO LEPTIN ACTION [J].

FREDERICH, RC ;

HAMANN, A ;

ANDERSON, S ;

LOLLMANN, B ;

LOWELL, BB ;

FLIER, JS .

NATURE MEDICINE, 1995, 1 (12) :1311-1314

[39] Obesity in the new millennium [J].

Friedman, JM .

NATURE, 2000, 404 (6778) :632-634

[40] Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice [J].

Fruebis, J ;

Tsao, TS ;

Javorschi, S ;

Ebbets-Reed, D ;

Erickson, MRS ;

Yen, FT ;

Bihain, BE ;

Lodish, HF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) :2005-2010

← 1 2 3 4 5 6 7 8 9 10 →