Adapting to obesity with adipose tissue inflammation

被引：906

作者：

Reilly, Shannon M. ^{[1
]}

Saltiel, Alan R. ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2017年 / 13卷 / 11期

关键词：

NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; INNATE LYMPHOID-CELLS; NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; TOLL-LIKE RECEPTOR; INSULIN-RESISTANCE; BEIGE FAT; T-CELLS; NLRP3; INFLAMMASOME;

D O I：

10.1038/nrendo.2017.90

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipose tissue not only has an important role in the storage of excess nutrients but also senses nutrient status and regulates energy mobilization. An overall positive energy balance is associated with overnutrition and leads to excessive accumulation of fat in adipocytes. These cells respond by initiating an inflammatory response that, although maladaptive in the long run, might initially be a physiological response to the stresses obesity places on adipose tissue. In this Review, we characterize adipose tissue inflammation and review the current knowledge of what triggers obesity-associated inflammation in adipose tissue. We examine the connection between adipose tissue inflammation and the development of insulin resistance and catecholamine resistance and discuss the ensuing state of metabolic inflexibility. Finally, we review the current and potential new anti-inflammatory treatments for obesity-associated metabolic disease.

引用

页码：633 / 643

页数：11

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