RETRACTED: Polymer nanodiscs and macro-nanodiscs of a varying lipid composition (Retracted article. See vol. 54, pg. 14033, 2018)

被引：38

作者：

Ramadugu, Venkata Sudheer Kumar

Di Mauro, Giacomo Maria

Ravula, Thirupathi

Ramamoorthy, Ayyalusamy ^{[1
]}

机构：

[1] Univ Michigan, Biophys Program, Ann Arbor, MI 48109 USA

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 78期

关键词：

DETERGENT-FREE ISOLATION; MEMBRANE-PROTEINS; NMR; SOLUBILIZATION; RECONSTITUTION; NANOPARTICLES; MODEL; SIZE;

D O I：

10.1039/c7cc06409h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymer lipid nanodiscs have enabled some exciting structural biology and nanobiotechnology applications. The use of a small molecular weight polymer (SMA-EA) has been demonstrated to dramatically increase the size of nanodiscs (up to similar to 60 nm diameter). Here, we report the first demonstration of the formation of macro-nanodiscs for a variety of lipids, and solid-state NMR experiments utilizing their magnetic-alignment properties.

引用

收藏

页码：10824 / 10826

页数：3

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共 25 条

[1] Fast Collisional Lipid Transfer Among Polymer-Bounded Nanodiscs [J].

Arenas, Rodrigo Cuevas ;

Danielczak, Bartholomaeus ;

Martel, Anne ;

Porcar, Lionel ;

Breyton, Cecile ;

Ebel, Christine ;

Keller, Sandro .

SCIENTIFIC REPORTS, 2017, 7

[2] Influence of lipid bilayer properties on nanodisc formation mediated by styrene/maleic acid copolymers [J].

Arenas, Rodrigo Cuevas ;

Klingler, Johannes ;

Vargas, Carolyn ;

Keller, Sandro .

NANOSCALE, 2016, 8 (32) :15016-15026

[3] Proton-Detected Solid-State NMR Spectroscopy of a Zinc Diffusion Facilitator Protein in Native Nanodiscs [J].

Bersch, Beate ;

Doerr, Jonas M. ;

Hessel, Audrey ;

Killian, J. Antoinette ;

Schanda, Paul .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (09) :2508-2512

[4] HETERONUCLEAR SOLID-STATE CORRELATION SPECTROSCOPY [J].

CARAVATTI, P ;

BODENHAUSEN, G ;

ERNST, RR .

CHEMICAL PHYSICS LETTERS, 1982, 89 (05) :363-367

[5] Tuning the size of styrene-maleic acid copolymer-lipid nanoparticles (SMALPs) using RAFT polymerization for biophysical studies [J].

Craig, Andrew F. ;

Clark, Emily E. ;

Sahu, Indra D. ;

Zhang, Rongfu ;

Frantz, Nick D. ;

Al-Abdul-Wahid, M. Sameer ;

Dabney-Smith, Carole ;

Konkolewicz, Dominik ;

Lorigan, Gary A. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2016, 1858 (11) :2931-2939

[6] Nanodiscs in Membrane Biochemistry and Biophysics [J].

Denisov, Ilia G. ;

Sligari, Stephen G. .

CHEMICAL REVIEWS, 2017, 117 (06) :4669-4713

[7] Nanodiscs for structural and functional studies of membrane proteins [J].

Denisov, Ilia G. ;

Sligar, Stephen G. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2016, 23 (06) :481-486

[8] Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel: The power of native nanodiscs [J].

Dorr, Jonas M. ;

Koorengevel, Martijn C. ;

Schafer, Marre ;

Prokofyev, Alexander V. ;

Scheidelaar, Stefan ;

van der Cruijsen, Elwin A. W. ;

Dafforn, Timothy R. ;

Baldus, Marc ;

Killian, J. Antoinette .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (52) :18607-18612

[9] Optimized Phospholipid Bilayer Nanodiscs Facilitate High-Resolution Structure Determination of Membrane Proteins [J].

Hagn, Franz ;

Etzkorn, Manuel ;

Raschle, Thomas ;

Wagner, Gerhard .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (05) :1919-1925

[10] Biology, structure and mechanism of P-type ATPases [J].

Kühlbrandt, W .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (04) :282-295