The Interaction between Arachidonic Acid Metabolism and Homocysteine

被引：10

作者：

Domi, Elisa ^{[1
]}

Hoxha, Malvina ^{[1
]}

Hoxha, Bianka ^{[1
]}

Zappacosta, Bruno ^{[1
]}

机构：

[1] Catholic Univ Our Lady Good Counsel, Fac Pharm, Dept Chem Toxicol & Pharmacol Evaluat Drugs, Rruga Dritan Hoxha, Tirana, Albania

来源：

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS | 2021年 / 21卷 / 07期

关键词：

Homocysteine; hyperhomocysteinemia; arachidonic acid; cardiovascular diseases; epoxyeicosatrienoic acids; Homeostasis; SOLUBLE EPOXIDE HYDROLASE; INFLAMMATORY MARKERS; RISK-FACTOR; HYPERHOMOCYSTEINEMIA; DISEASE; PROSTACYCLIN; EXPRESSION; PATHWAY; BRAIN; CYCLOOXYGENASE-2;

D O I：

10.2174/1871530320999200904130504

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperhomocysteinemia (HHcy) has been considered a risk factor for different diseases, including cardiovascular disease (CVD), inflammation, neurological diseases, cancer, and many other pathological conditions. Likewise, arachidonic acid (AA) metabolism is implicated in both vascular homeostasis and inflammation, as shown by the development of CVD, following the imbalance of its metabolites. This review summarizes how homocysteine (Hcy) can influence the metabolism of AA. In silico literature searches were performed on PubMed and Scopus as main sources. Several studies have shown that altered levels of Hcy, through AA release and metabolism, can influence the synthesis and the activity of prostaglandins (PGs), prostacyclin (PGI2), thromboxane (TXA), epoxyeicosatrienoic acids (EETs), and hydroxyeicosatetraenoic acids (HETEs). It is believed that by targeting Hcy in the AA pathways, novel compounds with better pharmacological and pharmacodynamics benefits may be obtained and that this information is valuable for a dietician to manipulate diets to improve health.

引用

页码：1232 / 1241

页数：10

共 105 条

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