The cloning expression and tissue distribution of human PP2Cβ

被引：27
|
作者：
Marley, AE [1 ]
Kline, A [1 ]
Crabtree, G [1 ]
Sullivan, JE [1 ]
Beri, RK [1 ]
机构：
[1] Zeneca Pharmaceut, Cardiovasc Musculoskeletal & Metab Dept, Macclesfield SK10 4TG, Cheshire, England
来源：
FEBS LETTERS | 1998年 / 431卷 / 01期
关键词：
protein phosphatase 2C; protein phosphorylation;
D O I：
10.1016/S0014-5793(98)00708-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have cloned a novel PP2C beta isoform from a human Liver cDNA library which codes for a protein homologous to other mammalian PP2C beta s at the N-terminus but with an extended C-terminus that is unique amongst the PP2Cs, The protein expressed in E. coli is indistinguishable from human recombinant PP2C alpha in its cation dependence and insensitivity to okadaic acid, Northern blot analysis of PP2C beta along with that of PP2C alpha shows that human PP2Cs are widely expressed and are most abundant in heart and skeletal muscle. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码：121 / 124
页数：4
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