Overexpression of RhoGDI2 correlates with the progression and prognosis of pancreatic carcinoma

被引：22

作者：

Yi, Bin ^{[1
]}

Zhang, Yi ^{[1
]}

Zhu, Dongming ^{[1
]}

Zhang, Lifeng ^{[1
]}

Song, Shiduo ^{[1
]}

He, Songbing ^{[1
,2
]}

Zhang, Bing ^{[3
]}

Li, Dechun ^{[1
]}

Zhou, Jian ^{[1
]}

机构：

[1] Soochow Univ, Dept Gen Surg, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200025, Peoples R China

[3] Soochow Univ, Dept Nucl Med, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China

来源：

ONCOLOGY REPORTS | 2015年 / 33卷 / 03期

关键词：

RhoGDI2; E-cadherin; pancreatic carcinoma; prognosis; GDP-DISSOCIATION INHIBITOR; GTP-BINDING PROTEIN; RHO-GTPASES; BLADDER-CANCER; EXPRESSION; EMT; METASTASIS; INVASION; MIGRATION;

D O I：

10.3892/or.2015.3707

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rho GDP dissociation inhibitor 2 (RhoGDI2) has been found to be a regulator of tumor metastasis. However, the expression of RhoGDI2 and its clinicopathological significance as well as the pathway of RhoGDI2 in tumor metastasis have yet to be investigated. To investigate the role of RhoGDI2 in the progression and prognosis of pancreatic carcinoma (PC), the expression of RhoGDI2 in human PC tissues was examined and compared with the clinicopathological characteristics and prognosis. Moreover, the relationship between RhoGDI2 and E-cadherin was examined. The results indicated that RhoGDI2 was overexpressed in PC tissues and associated with clinicopathological characteristics, including clinical stage and lymph node metastasis. Patients with a RhoGDI2-negative expression had a significantly longer survival time than those with a RhoGDI2-positive expression. Additionally, the expression of RhoGDI2 was negatively correlated with the expression of E-cadherin in PC tissues. Taken together, the findings suggest that RhoGDI2 is important in the progression and prognosis of PC, and may be used as a potential prognostic biomarker and a therapeutic target for PC.

引用

页码：1201 / 1206

页数：6

共 26 条

[1] Rictor regulates cell migration by suppressing RhoGDI2 [J].

Agarwal, N. K. ;

Chen, C-H ;

Cho, H. ;

Boulbes, D. R. ;

Spooner, E. ;

Sarbassov, D. D. .

ONCOGENE, 2013, 32 (20) :2521-2526

[2] BREAST CANCER Circulating and dynamic EMT [J].

Burgess, Darren J. .

NATURE REVIEWS CANCER, 2013, 13 (03) :148-149

[3] Proteomics-based Strategy to Delineate the Molecular Mechanisms of RhoGDI2-induced Metastasis and Drug Resistance in Gastric Cancer [J].

Cho, Hee Jun ;

Baek, Young Eun ;

Kim, In-Kyu ;

Park, Sun-Mi ;

Choi, Yeong-Lim ;

Nam, In-Koo ;

Park, Seung-Ho ;

Im, Min-Ju ;

Yoo, Jong-Min ;

Ryu, Ki-Jun ;

Oh, Young Taek ;

Hong, Soon-Chan ;

Kwon, Oh-Hyung ;

Kim, Jae Won ;

Lee, Chang Won ;

Yoo, Jiyun .

JOURNAL OF PROTEOME RESEARCH, 2012, 11 (04) :2355-2364

[4] RhoGDI2 as a therapeutic target in cancer [J].

Cho, Hee Jun ;

Baek, Kyoung Eun ;

Yoo, Jiyun .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2010, 14 (01) :67-75

[5]

CHUANG TH, 1993, J BIOL CHEM, V268, P775

[6] GDIs: central regulatory molecules in Rho GTPase activation [J].

DerMardirossian, C ;

Bokoch, GM .

TRENDS IN CELL BIOLOGY, 2005, 15 (07) :356-363

[7] RhoGDI: Multiple functions in the regulation of Rho family GTPase activities [J].

Dovas, A ;

Couchman, JR .

BIOCHEMICAL JOURNAL, 2005, 390 :1-9

[8] The 'invisible hand': regulation of RHO GTPases by RHOGDIs [J].

Garcia-Mata, Rafael ;

Boulter, Etienne ;

Burridge, Keith .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (08) :493-504

[9] The faces and friends of RhoGDI2 [J].

Griner, Erin M. ;

Theodorescu, Dan .

CANCER AND METASTASIS REVIEWS, 2012, 31 (3-4) :519-528

[10] A GDP DISSOCIATION INHIBITOR THAT SERVES AS A GTPASE INHIBITOR FOR THE RAS-LIKE PROTEIN CDC42HS [J].

HART, MJ ;

MARU, Y ;

LEONARD, D ;

WITTE, ON ;

EVANS, T ;

CERIONE, RA .

SCIENCE, 1992, 258 (5083) :812-815

← 1 2 3 →