Interleukin-2, interleukin-15, and their roles in human natural killer cells

被引：256

作者：

Becknell, B ^{[1
]}

Caligiuri, MA

机构：

[1] Ohio State Univ, Med Sci Program, Columbus, OH 43210 USA

[2] Ohio State Univ, Integrated Biomed Grad Program, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA

[4] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA

[5] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

ADVANCES IN IMMUNOLOGY, VOL 86 | 2005年 / 86卷

关键词：

D O I：

10.1016/S0065-2776(04)86006-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are CD56(+)CD3(-) large granular lymphocytes that constitute a key component of the human innate immune response. In addition to their potent cytolytic activity, NK cells elaborate a host of immunoregulatory cytokines and chemokines that play a crucial role in pathogen clearance. Furthermore, interactions between NK and other immune cells are implicated in triggering the adaptive, or antigen-specific, immune response. Interleukin-2 (IL-2) and IL-15 are two distinct cytokines with partially overlapping properties that are implicated in the development, homeostasis, and function of NK cells. This review examines the pervasive effects of IL-2 and IL-15 on NK cell biology, with an emphasis on recent discoveries and lingering challenges in the field.

引用

页码：209 / 239

页数：31

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