Interleukin-2, interleukin-15, and their roles in human natural killer cells

被引：255

作者：

Becknell, B ^{[1
]}

Caligiuri, MA

机构：

[1] Ohio State Univ, Med Sci Program, Columbus, OH 43210 USA

[2] Ohio State Univ, Integrated Biomed Grad Program, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA

[4] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA

[5] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

ADVANCES IN IMMUNOLOGY, VOL 86 | 2005年 / 86卷

关键词：

D O I：

10.1016/S0065-2776(04)86006-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are CD56(+)CD3(-) large granular lymphocytes that constitute a key component of the human innate immune response. In addition to their potent cytolytic activity, NK cells elaborate a host of immunoregulatory cytokines and chemokines that play a crucial role in pathogen clearance. Furthermore, interactions between NK and other immune cells are implicated in triggering the adaptive, or antigen-specific, immune response. Interleukin-2 (IL-2) and IL-15 are two distinct cytokines with partially overlapping properties that are implicated in the development, homeostasis, and function of NK cells. This review examines the pervasive effects of IL-2 and IL-15 on NK cell biology, with an emphasis on recent discoveries and lingering challenges in the field.

引用

页码：209 / 239

页数：31

共 111 条

[61] IDENTITY OF LEU-19 (CD56) LEUKOCYTE DIFFERENTIATION ANTIGEN AND NEURAL CELL-ADHESION MOLECULE [J].

LANIER, LL ;

TESTI, R ;

BINDL, J ;

PHILLIPS, JH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (06) :2233-2238

[62] Role of Jak kinases and STATS in cytokine signal transduction [J].

Leonard, WJ .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2001, 73 (03) :271-277

[63] Regulatory pathways involved in the infection-induced production of IFN-γ by NK cells [J].

Lieberman, LA ;

Hunter, CA .

MICROBES AND INFECTION, 2002, 4 (15) :1531-1538

[64] IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation [J].

Lodolce, JP ;

Boone, DL ;

Chai, S ;

Swain, RE ;

Dassopoulos, T ;

Trettin, S ;

Ma, A .

IMMUNITY, 1998, 9 (05) :669-676

[65]

LOTZOVA E, 1993, J IMMUNOL, V150, P5263

[66] EXPRESSION OF A FUNCTIONAL C-KIT RECEPTOR ON A SUBSET OF NATURAL-KILLER-CELLS [J].

MATOS, ME ;

SCHNIER, GS ;

BEECHER, MS ;

ASHMAN, LK ;

WILLIAMS, DE ;

CALIGIURI, MA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) :1079-1084

[67] IL-15 is expressed by dendritic cells in response to type IIFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation [J].

Mattei, F ;

Schiavoni, G ;

Belardelli, F ;

Tough, DF .

JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1179-1187

[68] Interleukin-15 (IL-15) induces NF-κB activation and IL-8 production in human neutrophils [J].

McDonald, PP ;

Russo, MP ;

Ferrini, S ;

Cassatella, MA .

BLOOD, 1998, 92 (12) :4828-4835

[69]

MILLER JS, 1992, BLOOD, V80, P2182

[70] Enforced expression of Bcl-2 restores the number of NK cells, but does not rescue the impaired development of NKT cells or intraepithelial lymphocytes, in IL-2/IL-15 receptor β-chain-deficient mice [J].

Minagawa, M ;

Watanabe, H ;

Miyaji, C ;

Tomiyama, K ;

Shimura, H ;

Ito, A ;

Ito, M ;

Domen, J ;

Weissman, IL ;

Kawai, K .

JOURNAL OF IMMUNOLOGY, 2002, 169 (08) :4153-4160

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