Interleukin-2, interleukin-15, and their roles in human natural killer cells

被引：256

作者：

Becknell, B ^{[1
]}

Caligiuri, MA

机构：

[1] Ohio State Univ, Med Sci Program, Columbus, OH 43210 USA

[2] Ohio State Univ, Integrated Biomed Grad Program, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA

[4] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA

[5] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

ADVANCES IN IMMUNOLOGY, VOL 86 | 2005年 / 86卷

关键词：

D O I：

10.1016/S0065-2776(04)86006-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are CD56(+)CD3(-) large granular lymphocytes that constitute a key component of the human innate immune response. In addition to their potent cytolytic activity, NK cells elaborate a host of immunoregulatory cytokines and chemokines that play a crucial role in pathogen clearance. Furthermore, interactions between NK and other immune cells are implicated in triggering the adaptive, or antigen-specific, immune response. Interleukin-2 (IL-2) and IL-15 are two distinct cytokines with partially overlapping properties that are implicated in the development, homeostasis, and function of NK cells. This review examines the pervasive effects of IL-2 and IL-15 on NK cell biology, with an emphasis on recent discoveries and lingering challenges in the field.

引用

页码：209 / 239

页数：31

共 111 条

[41] IDENTIFICATION AND CLONING OF A NOVEL IL-15 BINDING-PROTEIN THAT IS STRUCTURALLY RELATED TO THE ALPHA-CHAIN OF THE IL-2 RECEPTOR [J].

GIRI, JG ;

KUMAKI, S ;

AHDIEH, M ;

FRIEND, DJ ;

LOOMIS, A ;

SHANEBECK, K ;

DUBOSE, R ;

COSMAN, D ;

PARK, LS ;

ANDERSON, DM .

EMBO JOURNAL, 1995, 14 (15) :3654-3663

[42] Detection of a functional hybrid receptor γc/GM-CSFRβ in human hematopoietic CD34+ cells [J].

Giron-Michel, J ;

Fogli, M ;

Gaggero, A ;

Ferrini, S ;

Caignard, A ;

Brouty-Boyé, D ;

Baouz, S ;

Le Bousse-Kerdilès, MC ;

Péault, B ;

van Dijk, M ;

Bulfone-Paus, S ;

Durali, D ;

Chouaib, S ;

Azzarone, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (06) :763-775

[43] CLONING OF A T-CELL GROWTH-FACTOR THAT INTERACTS WITH THE BETA-CHAIN OF THE INTERLEUKIN-2 RECEPTOR [J].

GRABSTEIN, KH ;

EISENMAN, J ;

SHANEBECK, K ;

RAUCH, C ;

SRINIVASAN, S ;

FUNG, V ;

BEERS, C ;

RICHARDSON, J ;

SCHOENBORN, MA ;

AHDIEH, M ;

JOHNSON, L ;

ALDERSON, MR ;

WATSON, JD ;

ANDERSON, DM ;

GIRI, JG .

SCIENCE, 1994, 264 (5161) :965-968

[44] Inducible IL-2 production by dendritic cells revealed by global gene expression analysis [J].

Granucci, F ;

Vizzardelli, C ;

Pavelka, N ;

Feau, S ;

Persico, M ;

Virzi, E ;

Rescigno, M ;

Moro, G ;

Ricciardi-Castagnoli, P .

NATURE IMMUNOLOGY, 2001, 2 (09) :882-888

[45] Early IL-2 production by mouse dendritic cells is the result of microbial-induced priming [J].

Granucci, F ;

Feau, S ;

Angeli, W ;

Trottein, F ;

Ricciardi-Castagnoli, P .

JOURNAL OF IMMUNOLOGY, 2003, 170 (10) :5075-5081

[46] New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway [J].

Gu, HH ;

Maeda, H ;

Moon, JJ ;

Lord, JD ;

Yoakim, M ;

Nelson, BH ;

Neel, BG .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (19) :7109-7120

[47] Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity [J].

Imada, K ;

Bloom, ET ;

Nakajima, H ;

Horvath-Arcidiacono, JA ;

Udy, GB ;

Davey, HW ;

Leonard, WJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (11) :2067-2074

[48] EXPANSION OF NATURAL-KILLER CELLS BUT NOT T-CELLS IN HUMAN INTERLEUKIN-2 INTERLEUKIN-2 RECEPTOR (TAC) TRANSGENIC MICE [J].

ISHIDA, Y ;

NISHI, M ;

TAGUCHI, O ;

INABA, K ;

HATTORI, M ;

MINATO, N ;

KAWAICHI, M ;

HONJO, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1103-1115

[49] Rational interleukin 2 therapy for HIV positive individuals: Daily low doses enhance immune function without toxicity [J].

Jacobson, EL ;

Pilaro, F ;

Smith, KA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10405-10410

[50] Turnover and proliferation of NK cells in steady state and lymphopenic conditions [J].

Jamieson, AM ;

Isnard, P ;

Dorfman, JR ;

Coles, MC ;

Raulet, DH .

JOURNAL OF IMMUNOLOGY, 2004, 172 (02) :864-870

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