Interleukin-2, interleukin-15, and their roles in human natural killer cells

被引：252
作者：
Becknell, B [1 ]
Caligiuri, MA
机构：
[1] Ohio State Univ, Med Sci Program, Columbus, OH 43210 USA
[2] Ohio State Univ, Integrated Biomed Grad Program, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA
[4] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA
[5] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
来源：
ADVANCES IN IMMUNOLOGY, VOL 86 | 2005年 / 86卷
关键词：
D O I：
10.1016/S0065-2776(04)86006-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer (NK) cells are CD56(+)CD3(-) large granular lymphocytes that constitute a key component of the human innate immune response. In addition to their potent cytolytic activity, NK cells elaborate a host of immunoregulatory cytokines and chemokines that play a crucial role in pathogen clearance. Furthermore, interactions between NK and other immune cells are implicated in triggering the adaptive, or antigen-specific, immune response. Interleukin-2 (IL-2) and IL-15 are two distinct cytokines with partially overlapping properties that are implicated in the development, homeostasis, and function of NK cells. This review examines the pervasive effects of IL-2 and IL-15 on NK cell biology, with an emphasis on recent discoveries and lingering challenges in the field.
引用
收藏
页码：209 / 239
页数：31
相关论文
共 111 条
  • [101] INTERLEUKIN-2 - INCEPTION, IMPACT, AND IMPLICATIONS
    SMITH, KA
    [J]. SCIENCE, 1988, 240 (4856) : 1169 - 1176
  • [102] Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain
    Suzuki, H
    Duncan, GS
    Takimoto, H
    Mak, TW
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (03) : 499 - 505
  • [103] SELECTIVE LONG-TERM ELIMINATION OF NATURAL-KILLER-CELLS IN-VIVO BY AN ANTI-INTERLEUKIN-2 RECEPTOR BETA-CHAIN MONOCLONAL-ANTIBODY IN MICE
    TANAKA, T
    KITAMURA, F
    NAGASAKA, Y
    KUIDA, K
    SUWA, H
    MIYASAKA, M
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) : 1103 - 1107
  • [104] Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
    Teglund, S
    McKay, C
    Schuetz, E
    van Deursen, JM
    Stravopodis, D
    Wang, DM
    Brown, M
    Bodner, S
    Grosveld, G
    Ihle, JN
    [J]. CELL, 1998, 93 (05) : 841 - 850
  • [105] Waldmann TA, 2001, IMMUNITY, V14, P105, DOI 10.1016/S1074-7613(01)00093-0
  • [106] INTERLEUKIN-2 RECEPTOR-ALPHA CHAIN REGULATES THE SIZE AND CONTENT OF THE PERIPHERAL LYMPHOID COMPARTMENT
    WILLERFORD, DM
    CHEN, JZ
    FERRY, JA
    DAVIDSON, L
    MA, A
    ALT, FW
    [J]. IMMUNITY, 1995, 3 (04) : 521 - 530
  • [107] Generation of lytic natural killer 1.1(+), Ly-49(-) cells from multipotential murine bone marrow progenitors in a stroma-free culture: Definition of cytokine requirements and developmental intermediates
    Williams, NS
    Moore, TA
    Schatzle, JD
    Puzanov, IJ
    Sivakumar, PV
    Zlotnik, A
    Bennett, M
    Kumar, V
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (09) : 1609 - 1614
  • [108] Flt3 ligand promotes the generation of a distinct CD34+ human natural killer cell progenitor that responds to interleukin-15
    Yu, HX
    Fehniger, TA
    Fuchshuber, P
    Thiel, KS
    Vivier, E
    Carson, WE
    Caligiuri, MA
    [J]. BLOOD, 1998, 92 (10) : 3647 - 3657
  • [109] Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers
    Zhang, J
    Scordi, I
    Smyth, MJ
    Lichtenheld, MG
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (09) : 1297 - 1307
  • [110] A role for NF-κB activation in perforin expression of NK cells upon IL-2 receptor signaling
    Zhou, J
    Zhang, J
    Lichtenheld, MG
    Meadows, GG
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 169 (03) : 1319 - 1325
3456789101112