Interleukin-2, interleukin-15, and their roles in human natural killer cells

被引：256

作者：

Becknell, B ^{[1
]}

Caligiuri, MA

机构：

[1] Ohio State Univ, Med Sci Program, Columbus, OH 43210 USA

[2] Ohio State Univ, Integrated Biomed Grad Program, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA

[4] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA

[5] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

ADVANCES IN IMMUNOLOGY, VOL 86 | 2005年 / 86卷

关键词：

D O I：

10.1016/S0065-2776(04)86006-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are CD56(+)CD3(-) large granular lymphocytes that constitute a key component of the human innate immune response. In addition to their potent cytolytic activity, NK cells elaborate a host of immunoregulatory cytokines and chemokines that play a crucial role in pathogen clearance. Furthermore, interactions between NK and other immune cells are implicated in triggering the adaptive, or antigen-specific, immune response. Interleukin-2 (IL-2) and IL-15 are two distinct cytokines with partially overlapping properties that are implicated in the development, homeostasis, and function of NK cells. This review examines the pervasive effects of IL-2 and IL-15 on NK cell biology, with an emphasis on recent discoveries and lingering challenges in the field.

引用

页码：209 / 239

页数：31

共 111 条

[1]

ANDERSON DM, 1995, J BIOL CHEM, V270, P29862

[2] IL-15-mediated induction of LFA-1 is a late step required for cytotoxic differentiation of human NK cells from CD34+Lin- bone marrow cells [J].

Barao, I ;

Hudig, D ;

Ascensao, JL .

JOURNAL OF IMMUNOLOGY, 2003, 171 (02) :683-690

[3] PROLONGED ADMINISTRATION OF LOW-DOSE INTERLEUKIN-2 IN HUMAN IMMUNODEFICIENCY VIRUS-ASSOCIATED MALIGNANCY RESULTS IN SELECTIVE EXPANSION OF INNATE IMMUNE EFFECTORS WITHOUT SIGNIFICANT CLINICAL TOXICITY [J].

BERNSTEIN, ZP ;

PORTER, MM ;

GOULD, M ;

LIPMAN, B ;

BLUMAN, EM ;

STEWART, CC ;

HEWITT, RG ;

FYFE, G ;

POIESZ, B ;

CALIGIURI, MA .

BLOOD, 1995, 86 (09) :3287-3294

[4] INTERLEUKIN-2-INDUCED PROLIFERATION OF MURINE NATURAL-KILLER CELLS INVIVO [J].

BIRON, CA ;

YOUNG, HA ;

KASAIAN, MT .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (01) :173-188

[5] Fibroblasts from human spleen regulate NK cell differentiation from blood CD34+ progenitors via cell surface IL-15 [J].

Briard, D ;

Brouty-Boyé, D ;

Azzarone, B ;

Jasmin, C .

JOURNAL OF IMMUNOLOGY, 2002, 168 (09) :4326-4332

[6] SHWARTZMAN REACTION [J].

BROZNA, JP .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1990, 16 (04) :326-332

[7] RETRACTED: The IL-15Rα chain signals through association with Syk in human B cells (Retracted article. See vol. 186, pg. 2681, 2011) [J].

Bulanova, E ;

Budagian, V ;

Pohl, T ;

Krause, H ;

Dürkop, H ;

Paus, R ;

Bulfone-Paus, S .

JOURNAL OF IMMUNOLOGY, 2001, 167 (11) :6292-6302

[8] RETRACTED: Death deflected:: IL-15 inhibits TNF-α-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Rα chain (Retracted Article. See vol 25, pg 1118, 2011) [J].

Bulfone-Paus, S ;

Bulanova, E ;

Pohl, T ;

Budagian, V ;

Dürkop, H ;

Rückert, R ;

Kunzendorf, U ;

Paus, R ;

Krause, H .

FASEB JOURNAL, 1999, 13 (12) :1575-1585

[9] A LYMPHOKINE, PROVISIONALLY DESIGNATED INTERLEUKIN-T AND PRODUCED BY A HUMAN ADULT T-CELL LEUKEMIA LINE, STIMULATES T-CELL PROLIFERATION AND THE INDUCTION OF LYMPHOKINE-ACTIVATED KILLER-CELLS [J].

BURTON, JD ;

BAMFORD, RN ;

PETERS, C ;

GRANT, AJ ;

KURYS, G ;

GOLDMAN, CK ;

BRENNAN, J ;

ROESSLER, E ;

WALDMANN, TA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4935-4939

[10] SELECTIVE MODULATION OF HUMAN NATURAL-KILLER-CELLS INVIVO AFTER PROLONGED INFUSION OF LOW-DOSE RECOMBINANT INTERLEUKIN-2 [J].

CALIGIURI, MA ;

MURRAY, C ;

ROBERTSON, MJ ;

WANG, E ;

COCHRAN, K ;

CAMERON, C ;

SCHOW, P ;

ROSS, ME ;

KLUMPP, TR ;

SOIFFER, RJ ;

SMITH, KA ;

RITZ, J .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (01) :123-132

← 1 2 3 4 5 6 7 8 9 10 →