Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction

被引：15
作者：
Asmari, Mufarreh [1 ]
Wang, Xiaoyu [2 ]
Casado, Natalia [3 ]
Piponski, Marjan [4 ]
Kovalenko, Sergiy [5 ]
Logoyda, Liliya [6 ]
Hanafi, Rasha Sayed [7 ]
El Deeb, Sami [8 ]
机构：
[1] King Khalid Univ, Coll Pharm, Abha 62529, Saudi Arabia
[2] Univ Notre Dame, Dept Chem & Biomol Engn, Notre Dame, IN 46556 USA
[3] Univ Rey Juan Carlos, Dept Tecnol Quim & Ambiental, ESCET, C Tulipan S-N, Madrid 28933, Spain
[4] Replek Farm Ltd, St Kozle 188, Skopje 1000, North Macedonia
[5] Zaporizhzhia State Med Univ, Dept Organ & Bioorgan Chem, Maiakovskyi Ave 26, UA-69035 Zaporizhzhia, Ukraine
[6] I Horbachevsky Ternopil Natl Med Univ, Dept Pharmaceut Chem, Maidan Voli 1, UA-46001 Ternopol, Ukraine
[7] German Univ Cairo, Fac Pharm & Biotechnol, Dept Pharmaceut Chem, Cairo 11835, Egypt
[8] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, D-38106 Braunschweig, Germany
来源：
MOLECULES | 2021年 / 26卷 / 17期
关键词：
chiral chromatography; monolithic silica; chiral selector; immobilization; enantiomers; enantiomeric separation; enantiomeric impurity; molecular modeling; LIQUID-CHROMATOGRAPHIC-SEPARATION; DOUBLE-PORE SILICA; ONE-STEP STRATEGY; CAPILLARY COLUMNS; STATIONARY-PHASE; AMINO-ACIDS; POLYMER MONOLITHS; CLICK REACTION; SERUM-ALBUMIN; BONDED SILICA;
D O I：
10.3390/molecules26175241
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds. Properties and advantages of monolithic silica HPLC columns are also highlighted in comparison to conventional particle-packed, fused-core, and sub-2-mu m HPLC columns. Nano-LC capillary monolithic silica columns as well as polymeric-based and hybrid-based monolithic columns are also demonstrated to show good enantioresolution abilities. Methods for introducing the chiral selector into the monolithic silica column in the form of mobile phase additive, by encapsulation and surface coating, or by covalent functionalization are described. The application of molecular modeling methods to elucidate the selector-selectand interaction is discussed. An application for enantiomeric impurity determination is also considered.
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页数：18
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