Suzuki-Miyaura coupling reaction by PdII-catalyzed aromatic C-H bond activation directed by an N-alkyl acetamino group

被引：289
作者：
Shi, Zhangjie [1 ]
Li, Bijie
Wan, Xiaobing
Cheng, Jiang
Fang, Zhao
Cao, Bin
Qin, Changming
Wang, Yang
机构：
[1] Chinese Acad Sci, State Keu Lab Organomet Chem, Shanghai 200032, Peoples R China
[2] Peking Univ, PKU Green Chem Ctr, Coll Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
[3] Peking Univ, Coll Med, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China
[4] Wenzhou Univ, Coll Chem & Mat Sci, Wenzhou 3250027, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 29期
关键词：
C-C coupling; C-H activation; electrophilic substitution; palladium; Suzuki-Miyaura reaction;
D O I：
10.1002/anie.200700590
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) A seamless join: An efficient method to construct a C(sp2)-C(sp2) bond has been developed by using a Suzuki-Miyaura-type coupling of N-alkyl acetanilides with boronic acids. The reaction was catalyzed by a PdII species and the C-H bond activation was directed by the acetamino group (see scheme). This reaction offers a halogen-free method to construct complicated structures. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：5554 / 5558
页数：5
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