Minor Constituents in Rice Bran Oil and Sesame Oil Play a Significant Role in Modulating Lipid Homeostasis and Inflammatory Markers in Rats

被引：11
|
作者：
Yalagala, Poorna C. R. [1 ]
Sugasini, Dhavamani [1 ]
Ramaprasad, Talahalli Ravichandra [2 ]
Lokesh, Belur Ramaswamy [3 ]
机构：
[1] Univ Illinois, Dept Med, Sect Endocrinol Diabet & Metab MC 797, Chicago, IL USA
[2] CSIR, Cent Food Technol Res Inst, Dept Biochem & Nutr, Mysuru, Karnataka, India
[3] CSIR, Cent Food Technol Res Inst, Dept Lipid Sci, Mysuru 570020, Karnataka, India
来源：
JOURNAL OF MEDICINAL FOOD | 2017年 / 20卷 / 07期
关键词：
hypocholesterolemic effects; inflammatory mediators; minor constituents; oxidative stress markers; rice bran oil; sesame oil; FACTOR-KAPPA-B; HYDROGENATED VEGETABLE FAT; GAMMA-ORYZANOL; DOWN-REGULATION; MACROPHAGES; CHOLESTEROL; ACTIVATION; EXPRESSION; CELLS; PURIFICATION;
D O I：
10.1089/jmf.2016.3780
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effects of feeding rats with groundnut oil (GNO), rice bran oil (RBO), and sesame oil (SESO) on serum lipids, liver lipids, and inflammatory markers were evaluated in rats. Male Wistar rats were fed with AIN-93 diet supplemented with 10 wt% of GNO, RBO, and SESO in the form of native (N) and minor constituent-removed (MCR) oils. Rats given RBO and SESO showed significant reduction in serum and liver lipids, 8-hydroxy-2-deoxyguanosine, cytokines in liver, and eicosanoids in leukocytes as compared with the rats given GNO and MCR oils. The rats fed with native oils of RBO and SESO showed an upregulation of sterol regulatory element-binding protein (SREBP)-2 and peroxisome proliferator-activated receptor gamma (PPAR gamma) and downregulation of nuclear factor-kappa B (NF-kappa B) p65. These effects of native oil were significantly compromised when rats were given MCR oils. In conclusion, the minor constituents significantly support the hypolipidemic and anti-inflammatory properties of RBO and SESO.
引用
收藏
页码：709 / 719
页数：11
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