Anti-inflammatory and immune-mediated therapy for a case of febrile infection-related epilepsy syndrome with rapid recurrence

被引：11

作者：

Kurimoto, Tomonori ^{[1
]}

Matsuoka, Tsuyoshi ^{[1
]}

Ami, Yuki ^{[1
]}

Kanno, Koji ^{[1
]}

Fujii, Takashi ^{[1
]}

Fujiwara, Naoki ^{[1
]}

Matsuoka, Takashi ^{[1
]}

机构：

[1] Okinawa Prefectural Nanbu Med Ctr & Childrens Med, Dept Pediat, 118-1 Shinkawa, Haebaru, Okinawa 9011193, Japan

来源：

CLINICAL CASE REPORTS | 2022年 / 10卷 / 06期

关键词：

FIRES; granzymes B; high-dose PHB; IL-6; immune therapy; methylprednisolone; PDCD1; tacrolimus; tocilizumab; ENCEPHALITIS;

D O I：

10.1002/ccr3.5952

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Febrile infection-related epilepsy syndrome (FIRES) is a disease of unknown etiology, characterized by refractory frequent focal seizures, which require prolonged intensive care. We successfully treated a boy with FIRES with anti-inflammatory and immunosuppressive therapy. This case suggests that an autoimmune mechanism may play a role in the development of FIRES.

引用

页数：4

共 14 条

[1] Cytokine release syndrome. Reviewing a new entity in the intensive care unit [J].

Garcia Roche, Alejandra ;

Diaz Lagares, Candido ;

Elez, Elena ;

Ferrer Roca, Ricard .

MEDICINA INTENSIVA, 2019, 43 (08) :480-488

[2] New-onset refractory status epilepticus [J].

Gaspard, Nicolas ;

Foreman, Brandon P. ;

Alvarez, Vincent ;

Kang, Christian Cabrera ;

Probasco, John C. ;

Jongeling, Amy C. ;

Meyers, Emma ;

Espinera, Alyssa ;

Haas, Kevin F. ;

Schmitt, Sarah E. ;

Gerard, Elizabeth E. ;

Gofton, Teneille ;

Kaplan, Peter W. ;

Lee, Jong W. ;

Legros, Benjamin ;

Szaflarski, Jerzy P. ;

Westover, Brandon M. ;

LaRoche, Suzette M. ;

Hirsch, Lawrence J. .

NEUROLOGY, 2015, 85 (18) :1604-1613

[3] High dose phenobarbitone coma in pediatric refractory status epilepticus; a retrospective case record analysis, a proposed protocol and review of literature [J].

Gulati, Sheffali ;

Sondhi, Vishal ;

Chakrabarty, Biswaroop ;

Jauhari, Prashant ;

Lodha, Rakesh ;

Sankar, Jhuma .

BRAIN & DEVELOPMENT, 2018, 40 (04) :316-324

[4] Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions [J].

Hirsch, Lawrence J. ;

Gaspard, Nicolas ;

van Baalen, Andreas ;

Nabbout, Rima ;

Demeret, Sophie ;

Loddenkemper, Tobias ;

Navarro, Vincent ;

Specchio, Nicola ;

Lagae, Lieven ;

Rossetti, Andrea O. ;

Hocker, Sara ;

Gofton, Teneille E. ;

Abend, Nicholas S. ;

Gilmore, Emily J. ;

Hahn, Cecil ;

Khosravani, Houman ;

Rosenow, Felix ;

Trinka, Eugen .

EPILEPSIA, 2018, 59 (04) :739-744

[5]

IIVANAINEN M, 1983, ACTA NEUROL SCAND, V68, P49

[6] Etiology is the key determinant of neuroinflammation in epilepsy: Elevation of cerebrospinal fluid cytokines and chemokines in febrile infection-related epilepsy syndrome and febrile status epilepticus [J].

Kothur, Kavitha ;

Bandodkar, Sushil ;

Wienholt, Louise ;

Chu, Stephanie ;

Pope, Alun ;

Gill, Deepak ;

Dale, Russell C. .

EPILEPSIA, 2019, 60 (08) :1678-1688

[7] The role of inflammation in the development of epilepsy [J].

Rana, Amna ;

Musto, Alberto E. .

JOURNAL OF NEUROINFLAMMATION, 2018, 15

[8] Tocilizumab in Refractory Autoimmune Encephalitis: A Series of Pediatric Cases [J].

Randell, Rachel L. ;

Adams, Ashley V. ;

Van Mater, Heather .

PEDIATRIC NEUROLOGY, 2018, 86 :66-68

[9] Acute encephalitis with refractory, repetitive partial seizures (AERRPS): a peculiar form of childhood encephalitis [J].

Sakuma, H. ;

Awaya, Y. ;

Shiomi, M. ;

Yamanouchi, H. ;

Takahashi, Y. ;

Saito, Y. ;

Sugai, K. ;

Sasaki, M. .

ACTA NEUROLOGICA SCANDINAVICA, 2010, 121 (04) :251-256

[10] COMPLICATIONS ASSOCIATED WITH BARBITURATE THERAPY [J].

SATO, M ;

TANAKA, S ;

SUZUKI, K ;

KOHAMA, A ;

FUJII, C .

RESUSCITATION, 1989, 17 (03) :233-241

← 1 2 →