The Infectious Aspects of Atopic Dermatitis

被引：79

作者：

Ong, Peck Y. ^{[2
,3
]}

Leung, Donald Y. M. ^{[1
,4
]}

机构：

[1] Natl Jewish Hlth, Div Pediat Allergy Immunol, Denver, CO 80206 USA

[2] Childrens Hosp Los Angeles, Div Clin Immunol & Allergy, Los Angeles, CA 90027 USA

[3] Univ So Calif, Dept Pediat, Keck Sch Med, Los Angeles, CA 90089 USA

[4] Univ Colorado, Dept Pediat, Denver, CO 80202 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2010年 / 30卷 / 03期

关键词：

S aureus; Eczema herpeticum; Eczema vaccinatum; Superantigen; Toll-like receptors; Malassezia; OF-FUNCTION MUTATIONS; FILAGGRIN GENE PREDISPOSE; INNATE IMMUNE-RESPONSE; SKIN BARRIER FUNCTION; ALLERGY CLIN IMMUNOL; STAPHYLOCOCCUS-AUREUS; VACCINIA VIRUS; EARLY-ONSET; ANTIMICROBIAL PEPTIDES; MALASSEZIA-SYMPODIALIS;

D O I：

10.1016/j.iac.2010.05.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis is characterized by Staphylococcus aureus colonization and recurrent skin infections. In addition to an increased risk of invasive infections by herpes simplex or vaccinia viruses, there is ample evidence that microbial pathogens, particularly S aureus and fungi, contribute to the cutaneous inflammation of atopic dermatitis. The authors describe recent developments in the pathogenesis of atopic dermatitis in relation to the role of microbial pathogens. Understanding how microbial pathogens interact or evade the cutaneous immunity of atopic dermatitis may be crucial in preventing infections or cutaneous inflammation in this disease.

引用

页码：309 / +

页数：14

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