Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy

被引：22

作者：

Boudhabhay, Idris ^{[1
,2
]}

Rabant, Marion ^{[2
]}

Roumenina, Lubka T. ^{[3
]}

Coupry, Louis-Marie ^{[1
]}

Poillerat, Victoria ^{[3
]}

Marchal, Armance ^{[4
]}

Fremeaux-Bacchi, Veronique ^{[4
]}

El Karoui, Khalil ^{[5
]}

Monchi, Mehran ^{[1
]}

Pourcine, Franck ^{[1
,6
]}

机构：

[1] Grp Hosp Sud Ile France, Serv Reanimat, Melun, France

[2] CHU Necker, Serv Anat Pathol, Paris, France

[3] Univ Paris, Sorbonne Univ, INSERM, Ctr Rech Cordeliers, Paris, France

[4] Hop Europeen Georges Pompidou, Lab Immunol Biol, Paris, France

[5] CHU Henri Mondor, Serv Nephrol & Transplantat, Creteil, France

[6] Grp Hosp Sud Ile France, Serv Nephrol, Melun, France

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

thrombotic microangiopathy; multisystem inflammatory syndrome; COVID-19; complement system; eculizumab; case report; CORONAVIRUS DISEASE 2019; CLINICAL CHARACTERISTICS; COVID-19; ECULIZUMAB;

D O I：

10.3389/fimmu.2021.680567

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. A clinical series of Kawasaki-like multisystem inflammatory syndrome (MIS), occurring after SARS-CoV-2 infection, have been described in children (MIS-C) and adults (MIS-A), but the pathophysiology remains unknown. Case Presentation We describe a case of post-COVID-19 MIS-A in a 46-year-old man with biopsy-proven renal thrombotic microangiopathy (TMA). Specific complement inhibition with eculizumab was initiated promptly and led to a dramatic improvement of renal function. Conclusion Our case suggests that that TMA could play a central role in the pathophysiology of post-COVID-19 MIS-A, making complement blockers an interesting therapeutic option.

引用

页数：6

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