Proton Beam Therapy Combined with Concurrent Chemotherapy for Esophageal Cancer

被引：2
作者：
Ishikawa, Hitoshi [1 ]
Hashimoto, Takayuki [1 ]
Moriwaki, Toshikazu [2 ]
Hyodo, Ichinosuke [2 ]
Hisakura, Katsuji [3 ]
Terashima, Hideo [3 ]
Ohkohchi, Nobuhiro [3 ]
Ohno, Toshiki [1 ]
Makishima, Hirokazu [1 ]
Mizumoto, Masashi [1 ]
Ohnishi, Kayoko [1 ]
Okumura, Toshiyuki [1 ]
Sakurai, Hideyuki [1 ]
机构：
[1] Univ Tsukuba, Fac Med, Dept Radiat Oncol, Tsukuba, Ibaraki 3058575, Japan
[2] Univ Tsukuba, Fac Med, Dept Gastroenterol, Tsukuba, Ibaraki 3058575, Japan
[3] Univ Tsukuba, Fac Med, Dept Gastroenterol & Hepatobiliary Surg, Tsukuba, Ibaraki 3058575, Japan
来源：
ANTICANCER RESEARCH | 2015年 / 35卷 / 03期
关键词：
Proton beam therapy; esophageal cancer; concurrent chemoradiotherapy; survival; late toxicity; SQUAMOUS-CELL CARCINOMA; TERM-FOLLOW-UP; RADIATION-THERAPY; DEFINITIVE CHEMORADIOTHERAPY; PHASE-II; CHEMORADIATION; TRIAL; IRRADIATION; EFFUSION; SURGERY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: The aim of the present study was to evaluate the outcomes of proton beam therapy (PBT) concurrently combined with chemotherapy consisting of cisplatin and 5-fluorouracil for esophageal cancer. Patients and Methods: Forty consecutive patients (stage I in 16 patients, II in 9 and III in 15) treated between 2008 and 2012 were evaluated. A total dose of 60 Gray equivalents (GyE) in 30 fractions was delivered, and an additional boost of 4-10 GyE was given when residual tumors were suspected. The median follow-up time was 24 months (range=7-66 months). Results: No cardio-pulmonary toxicities of grade 3 or higher were observed. Recurrences were observed in 16 patients, and the 2-year rates of disease-specific survival and locoregional control were 77% and 66%, respectively. Conclusion: Irrespective of the small sample size and short follow-up time of the study, proton beam therapy combined with chemotherapy seems to be feasible for esophageal cancer.
引用
收藏
页码：1757 / 1762
页数：6
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