A conduit to metastasis: circulating tumor cell biology

被引：351

作者：

Micalizzi, Douglas S. ^{[1
,2
]}

Maheswaran, Shyamala ^{[1
,3
]}

Haber, Daniel A. ^{[1
,2
,4
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp Canc Ctr, Charlestown, MA 02129 USA

[2] Harvard Med Sch, Dept Med, Charlestown, MA 02129 USA

[3] Harvard Med Sch, Dept Surg, Charlestown, MA 02129 USA

[4] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

GENES & DEVELOPMENT | 2017年 / 31卷 / 18期

基金：

美国国家卫生研究院;

关键词：

blood-based diagnostics; cancer metastasis; circulating tumor cells; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER METASTASIS; NATURAL-KILLER-CELLS; TIME IMAGING REVEALS; ENDOTHELIAL BARRIER; DISTANT METASTASIS; PERIPHERAL-BLOOD; DNA METHYLATION; LUNG METASTASIS; SURVIVAL;

D O I：

10.1101/gad.305805.117

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Advances in the enrichment and analysis of rare cells from the bloodstreamhave allowed for detection and characterization of circulating tumor cells (CTCs) from patients with cancer. The analysis of CTCs has provided significant insight into the metastatic process. Studies on the biology of CTCs have begun to elucidate the molecular mechanisms of CTC generation, intravasation, survival, interactions with components of the blood, extravasation, and colonization of distant organs. Additionally, the study of CTCs has exposed dramatic intrapatient and interpatient heterogeneity and their evolution over time. In this review, we focus on the current knowledge of CTC biology and the potential clinical implications.

引用

页码：1827 / 1840

页数：14

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